Ketamine ( DrugBank: Ketamine )


6 diseases
告示番号疾患名(ページ内リンク)臨床試験数
6パーキンソン病3
13多発性硬化症/視神経脊髄炎2
70広範脊柱管狭窄症4
113筋ジストロフィー1
156レット症候群1
215ファロー四徴症1

6. パーキンソン病


臨床試験数 : 2,307 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
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agemax
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PhaseCountries
1EUCTR2021-000041-40-NL
(EUCTR)
22/02/202210/11/2021A study to investigate the effects of repeated low doses of psilocybin and ketamine on cognitive and emotional dysfunctions in Parkinson’s disease and to understand its mechanism of actionA study to investigate the effects of repeated low doses of psilocybin and ketamine on cognitive and emotional dysfunctions in Parkinson’s disease and to understand its mechanism of action - Microdosing and Parkinson’s disease Parkinson's disease;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]Product Name: Psilocybin
INN or Proposed INN: Psilocybine
Product Name: Ketamine
INN or Proposed INN: KETAMINE
Maastricht UniversityNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
34Phase 2Netherlands
2NCT04944017
(ClinicalTrials.gov)
November 23, 202122/6/2021Ketamine for the Treatment of Depression in Parkinson's DiseaseKetamine for the Treatment of Depression in Parkinson's Disease (KET-PD)Parkinson's Disease;DepressionDrug: Ketamine Infusion;Other: Placebo - Saline InfusionYale UniversityFox (Michael J.) Foundation for Parkinson's ResearchRecruiting40 Years80 YearsAll56Phase 2United States
3NCT04912115
(ClinicalTrials.gov)
October 5, 202125/5/2021Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced DyskinesiaA Multi-Center, Phase II, Randomized, Double-Blind, Prospective, Active Placebo- Controlled Trial of Sub-Anesthetic Intravenous Infusion of Ketamine to Treat Levodopa- Induced Dyskinesia in Subjects With Parkinson's DiseaseDyskinesias;Movement Disorders;Central Nervous System Diseases;Nervous System Diseases;Neurologic ManifestationsDrug: Ketamine;Drug: MidazolamPharmaTher Inc.NULLSuspended30 Years85 YearsAll30Phase 2United States

13. 多発性硬化症/視神経脊髄炎


臨床試験数 : 3,340 薬物数 : 2,163 - (DrugBank : 383) / 標的遺伝子数 : 241 - 標的パスウェイ数 : 238
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
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size
PhaseCountries
1NCT05378100
(ClinicalTrials.gov)
January 1, 202312/5/2022Ketamine for Multiple Sclerosis FatigueLow-Dose Ketamine Infusion for the Treatment of Multiple Sclerosis Fatigue (INKLING-MS)Multiple Sclerosis FatigueDrug: Ketamine;Drug: MidazolamJohns Hopkins UniversityUnited States Department of DefenseRecruiting18 Years65 YearsAll110Phase 2United States
2NCT03500289
(ClinicalTrials.gov)
August 10, 20184/4/2018Ketamine for Treatment of MS FatigueKetamine for Treatment of Multiple Sclerosis-related FatigueMultiple Sclerosis;FatigueDrug: Ketamine;Drug: MidazolamJohns Hopkins UniversityNational Multiple Sclerosis SocietyCompleted18 Years65 YearsAll18Phase 1/Phase 2United States

70. 広範脊柱管狭窄症


臨床試験数 : 95 薬物数 : 169 - (DrugBank : 61) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 90
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
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size
PhaseCountries
1NCT03088306
(ClinicalTrials.gov)
July 1, 201722/2/2017Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery PatientsComparative Effectiveness of Multi-modal Pain Management Versus Standard Intra- and Post-operative Analgesia: Randomized Controlled Clinical Trial to Reduce Post-operative Pain and Opioid Use Among Patients Undergoing Lumbar Spine SurgeryLumbar Spinal Stenosis;Lumbar Spinal Instability;Lumbar Spine DegenerationDrug: Standard analgesia use [Oxygen];Drug: Standard analgesia use [Hydromorphone];Drug: Standard analgesia use [Volatile Anesthesia];Drug: Standard analgesia use [Fentanyl];Drug: Multi-modal pain management [Acetaminophen + Gabapentin];Drug: Multi-modal pain management [Fentanyl];Drug: Multi-modal pain management [Intravenous Ketamine];Drug: Multi-modal pain management [Valium + Gabapentin]Johns Hopkins UniversityNorth American Spine SocietyCompleted18 Years100 YearsAll49Early Phase 1United States
2EUCTR2016-002887-14-FI
(EUCTR)
31/10/201614/10/2016Dose-response of ketamine in patient controlled analgesia in orthopaedic surgery patientsDose response study of Patient Controlled Analgesia (PCA) of S-ketamine in orthopaedic spine surgery patients - DoseRespKeta Patients who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation
MedDRA version: 19.0;Level: LLT;Classification code 10041595;Term: Spinal stenosis lumbar;System Organ Class: 100000004859;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11]
Trade Name: Ketanest-S
INN or Proposed INN: KETAMINE
Trade Name: Oxycodone Orion
INN or Proposed INN: OXYCODONE
University of TurkuNULLNot RecruitingFemale: yes
Male: yes
100Phase 1;Phase 4Finland
3EUCTR2012-000747-26-FI
(EUCTR)
27/04/201202/04/2012Ketamine to reduce postoperative pain in back surgeryAdministration of S-Ketamine during spinal surgery to reduce postoperative pain adult patients undergoing spinal surgery
MedDRA version: 14.1;Level: LLT;Classification code 10041595;Term: Spinal stenosis lumbar;System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders ;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
Trade Name: Ketanest-S
Product Name: Ketanest-S
Other descriptive name: ESKETAMINE HYDROCHLORIDE
Helsinki Universiy Central HospitalNULLNot Recruiting Female: yes
Male: yes
192 Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): yesFinland
4NCT01275547
(ClinicalTrials.gov)
January 201111/1/2011The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal MidazolamThe Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery PatientsAnalgesia, Patient-controlled;Spinal StenosisDrug: s-ketamine & midazolam;Drug: Morphine PCAUniversity Hospital, Basel, SwitzerlandNULLCompleted18 YearsN/ABoth22Phase 2/Phase 3Switzerland

113. 筋ジストロフィー


臨床試験数 : 646 薬物数 : 471 - (DrugBank : 105) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 170
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
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gender
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size
PhaseCountries
1NCT01645098
(ClinicalTrials.gov)
August 20118/6/2012Sedation During Muscle Biopsy in Patients With Duchenne Muscular DystrophySedation During Muscle Biopsy in Patients With Duchenne Muscular DystrophyDuchenne Muscular DystrophyDrug: Ketamine;Drug: DexmedetomidineNationwide Children's HospitalNULLCompletedN/AN/AMale53N/AUnited States

156. レット症候群


臨床試験数 : 44 薬物数 : 61 - (DrugBank : 23) / 標的遺伝子数 : 57 - 標的パスウェイ数 : 83
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT03633058
(ClinicalTrials.gov)
March 12, 20198/8/2018A Study to Evaluate Ketamine for the Treatment of Rett SyndromeA Randomized, Double-blind, Placebo-controlled, Cross-over Study to Assess the Safety, Tolerability and Efficacy of Oral Ketamine for Patients With Rett SyndromeRett SyndromeDrug: KetamineRett Syndrome Research TrustVanderbilt University Medical CenterCompleted6 Years12 YearsFemale24Phase 2United States

215. ファロー四徴症


臨床試験数 : 18 薬物数 : 26 - (DrugBank : 14) / 標的遺伝子数 : 13 - 標的パスウェイ数 : 45
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1ChiCTR-IOR-16008571
2016-06-062016-05-31Premedication for children with Tetralogy of FallotA comparative evalution of varies premedication regimes on children with Tetralogy of Fallot Tetralogy of Fallotoral dexmedetomidine:oral dexmedetomidine;oral ketamine:oral ketamine;oral dexmedetomidine mixed with ketamine:oral dexmedetomidine mixed with ketamine;Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong UniversityNULLRecruitingBothoral dexmedetomidine:20;oral ketamine:20;oral dexmedetomidine mixed with ketamine:20;China