Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 IFNG 6件: TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D04242 Fontolizumab 1件: 46
2 IFNG 6件: TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D11120 Emapalumab 2件: 49, 107
3 SMAD7 1件: TGF-beta signaling pathway D10956 Mongersen 2件: 96, 97
4 RGMA 1件: TGF-beta signaling pathway D11355 Elezanumab 1件: 13
5 ROCK1 4件: Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Yersinia infection D07941 Fasudil 4件: 2, 5, 7, 51
6 BMPR2 1件: TGF-beta signaling pathway D03779 Dibotermin alfa 1件: 34
7 TGFB1 4件: TGF-beta signaling pathway, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D09620 Fresolimumab 4件: 51, 85, 222, 274
8 TGFB2 3件: TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis D09620 Fresolimumab 4件: 51, 85, 222, 274
9 TGFB3 3件: TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis D09620 Fresolimumab 4件: 51, 85, 222, 274
10 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00742 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298
11 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
12 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
13 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02597 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271
14 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02598 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
15 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D03441 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271
16 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04358 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271
17 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04687 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331
18 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D05393 Pegsunercept 1件: 46
19 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D08976 Pomalidomide 6件: 28, 34, 51, 85, 227, 331
20 TNF 9件: Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D09944 Ozoralizumab 1件: 46
21 ACVR2A 1件: TGF-beta signaling pathway D09670 Sotatercept 2件: 86, 284
22 ACVR2A 1件: TGF-beta signaling pathway D10620 Bimagrumab 1件: 15
23 ACVR2B 1件: TGF-beta signaling pathway D10620 Bimagrumab 1件: 15