Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 MAPK14 23件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer D09639 Losmapimod 2件: 113, 222
2 MAPK14 23件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer D10959 Neflamapimod 1件: 8
3 F2 2件: Platelet activation, Regulation of actin cytoskeleton D06410 Thrombomodulin Alfa 1件: 85
4 F2 2件: Platelet activation, Regulation of actin cytoskeleton D07144 Dabigatran etexilate 1件: 51
5 F2 2件: Platelet activation, Regulation of actin cytoskeleton D09707 Dabigatran 4件: 51, 85, 91, 124
6 FYN 5件: Sphingolipid signaling pathway, Platelet activation, T cell receptor signaling pathway, Prion disease, Viral myocarditis D03658 Dasatinib 2件: 51, 85
7 FYN 5件: Sphingolipid signaling pathway, Platelet activation, T cell receptor signaling pathway, Prion disease, Viral myocarditis D06414 Dasatinib 2件: 51, 85
8 GUCY1A2 5件: Purine metabolism, Vascular smooth muscle contraction, Platelet activation, Renin secretion, Salivary secretion D00517 Amyl Nitrite 1件: 58
9 GUCY1A2 5件: Purine metabolism, Vascular smooth muscle contraction, Platelet activation, Renin secretion, Salivary secretion D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
10 GUCY1A1 5件: Purine metabolism, Vascular smooth muscle contraction, Platelet activation, Renin secretion, Salivary secretion D00517 Amyl Nitrite 1件: 58
11 GUCY1A1 5件: Purine metabolism, Vascular smooth muscle contraction, Platelet activation, Renin secretion, Salivary secretion D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
12 GUCY1B1 5件: Purine metabolism, Vascular smooth muscle contraction, Platelet activation, Renin secretion, Salivary secretion D00517 Amyl Nitrite 1件: 58
13 GUCY1B1 5件: Purine metabolism, Vascular smooth muscle contraction, Platelet activation, Renin secretion, Salivary secretion D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
14 PIK3CA 27件: Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
15 PIK3CB 27件: Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
16 PIK3CD 27件: Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
17 PIK3CD 27件: Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11437 Parsaclisib 3件: 35, 53, 61
18 MAPK11 23件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer D09639 Losmapimod 2件: 113, 222
19 MAPK11 23件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer D10959 Neflamapimod 1件: 8
20 MAPK13 23件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer D09639 Losmapimod 2件: 113, 222
21 MAPK13 23件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer D10959 Neflamapimod 1件: 8
22 PTGIR 2件: Vascular smooth muscle contraction, Platelet activation D00106 Epoprostenol 1件: 86
23 PTGIR 2件: Vascular smooth muscle contraction, Platelet activation D01337 Epoprostenol 1件: 86
24 PTGIR 2件: Vascular smooth muscle contraction, Platelet activation D01385 Ibudilast 2件: 2, 13
25 PTGIR 2件: Vascular smooth muscle contraction, Platelet activation D02720 Beraprost 1件: 86
26 PTGIR 2件: Vascular smooth muscle contraction, Platelet activation D02721 Iloprost 4件: 51, 84, 85, 86
27 PTGIR 2件: Vascular smooth muscle contraction, Platelet activation D06213 Treprostinil 6件: 51, 84, 85, 86, 88, 210
28 PTGIR 2件: Vascular smooth muscle contraction, Platelet activation D09994 Selexipag 6件: 47, 51, 70, 84, 86, 88
29 PTGIR 2件: Vascular smooth muscle contraction, Platelet activation D10725 Ralinepag 1件: 86
30 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00109 Acetylsalicylic acid 15件: 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251
31 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00118 Naproxen 4件: 13, 46, 107, 271
32 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00120 Sulindac 1件: 206
33 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00126 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299
34 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00132 Ketoprofen 1件: 46
35 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00141 Indomethacin 3件: 225, 271, 298
36 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00217 Acetaminophen 18件: 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
37 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00330 Flurbiprofen 3件: 13, 21, 46
38 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00428 Salsalate 1件: 5
39 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00813 Ketorolac 2件: 70, 226
40 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00903 Diclofenac 5件: 13, 34, 46, 78, 271
41 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00904 Diclofenac 5件: 13, 34, 46, 78, 271
42 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01122 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299
43 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01183 Tolfenamic acid 1件: 5
44 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01475 Flurbiprofen 3件: 13, 21, 46
45 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01545 Aceclofenac 1件: 46
46 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01565 Indomethacin 3件: 225, 271, 298
47 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D02110 Indomethacin 3件: 225, 271, 298
48 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D02290 Flurbiprofen 3件: 13, 21, 46
49 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D04490 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299
50 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D06606 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299
51 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D07816 Diclofenac 5件: 13, 34, 46, 78, 271
52 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D08104 Ketorolac 2件: 70, 226
53 PTGS1 3件: Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D08149 Loxoprofen 2件: 46, 271
54 ROCK1 9件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Shigellosis, Yersinia infection, Proteoglycans in cancer D07941 Fasudil 4件: 2, 5, 7, 51
55 MAPK12 23件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer D09639 Losmapimod 2件: 113, 222
56 MAPK12 23件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Proteoglycans in cancer D10959 Neflamapimod 1件: 8
57 P2RY12 1件: Platelet activation D00769 Clopidogrel 2件: 49, 86
58 P2RY12 1件: Platelet activation D07729 Clopidogrel 2件: 49, 86
59 P2RY12 1件: Platelet activation D09017 Ticagrelor 3件: 36, 46, 85
60 P2RY12 1件: Platelet activation D10823 Clopidogrel 2件: 49, 86
61 P2RY12 1件: Platelet activation D10824 Clopidogrel 2件: 49, 86
62 SRC 13件: Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis, Proteoglycans in cancer D03252 Bosutinib 2件: 2, 67
63 SRC 13件: Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis, Proteoglycans in cancer D03658 Dasatinib 2件: 51, 85
64 SRC 13件: Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis, Proteoglycans in cancer D06414 Dasatinib 2件: 51, 85
65 SRC 13件: Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis, Proteoglycans in cancer D09664 Saracatinib 3件: 6, 89, 272
66 SYK 3件: Platelet activation, Tuberculosis, Viral carcinogenesis D09347 Fostamatinib 4件: 46, 49, 61, 66
67 TBXA2R 1件: Platelet activation D01128 Ramatroban 1件: 13
68 TBXA2R 1件: Platelet activation D01896 Cilostazol 3件: 51, 70, 124
69 TBXA2R 1件: Platelet activation D04500 Ifetroban 3件: 51, 86, 113
70 BTK 2件: Platelet activation, Primary immunodeficiency D10223 Ibrutinib 3件: 28, 60, 61
71 BTK 2件: Platelet activation, Primary immunodeficiency D10893 Acalabrutinib 2件: 46, 61
72 BTK 2件: Platelet activation, Primary immunodeficiency D11422 Zanubrutinib 2件: 300, 331
73 BTK 2件: Platelet activation, Primary immunodeficiency D11457 Fenebrutinib 1件: 13
74 BTK 2件: Platelet activation, Primary immunodeficiency D11478 Branebrutinib 3件: 46, 49, 53
75 BTK 2件: Platelet activation, Primary immunodeficiency D12160 Orelabrutinib 3件: 13, 61, 63
76 VWF 1件: Platelet activation D11160 Caplacizumab 1件: 64
77 ROCK2 10件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection, Yersinia infection, Proteoglycans in cancer D07941 Fasudil 4件: 2, 5, 7, 51
78 ROCK2 10件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Platelet activation, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection, Yersinia infection, Proteoglycans in cancer D11815 Belumosudil 1件: 51