Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 SIGMAR1 💬 2件: Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
2 CYP46A1 💬 1件: Primary bile acid biosynthesis Soticlestat 💬 Soticlestat 2件: 140, 144 💬
3 CNR1 💬 4件: Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endocannabinoid signaling Cannabidiol 💬 Cannabidiol 20件: 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
4 CNR2 💬 1件: Neuroactive ligand-receptor interaction Cannabidiol 💬 Cannabidiol 20件: 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
5 GABRA1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
6 GABRA1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
7 GABRA2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
8 GABRA2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
9 GABRA3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
10 GABRA3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
11 GABRA4 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
12 GABRA4 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
13 GABRA5 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
14 GABRA5 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
15 GABRA6 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
16 GABRA6 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
17 GABRB1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
18 GABRB1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
19 GABRB2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
20 GABRB2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
21 GABRB3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
22 GABRB3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
23 GABRD 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
24 GABRD 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
25 GABRE 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
26 GABRE 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
27 GABRG1 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
28 GABRG1 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
29 GABRG2 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
30 GABRG2 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
31 GABRG3 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
32 GABRG3 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
33 GABRP 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
34 GABRP 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
35 GRIA1 💬 14件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
36 GRIA1 💬 14件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction Perampanel 💬 Perampanel 3件: 2, 6, 144 💬
37 GRIA2 💬 15件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
38 GRIA2 💬 15件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction Perampanel 💬 Perampanel 3件: 2, 6, 144 💬
39 GRIA3 💬 13件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction, Transcriptional misregulation in cancer Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
40 GRIA3 💬 13件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction, Transcriptional misregulation in cancer Perampanel 💬 Perampanel 3件: 2, 6, 144 💬
41 GRIA4 💬 10件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Huntington disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
42 GRIA4 💬 10件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Huntington disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction Perampanel 💬 Perampanel 3件: 2, 6, 144 💬
43 GRIK1 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
44 GRIK2 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
45 GRIK3 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
46 GRIK4 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
47 GRIK5 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
48 HTR1D 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
49 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
50 HTR2C 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
51 KCNQ1 💬 6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection Ezogabine 💬 Ezogabine 2件: 2, 144 💬
52 KCNQ2 💬 1件: Cholinergic synapse Ezogabine 💬 Ezogabine 2件: 2, 144 💬
53 KCNQ3 💬 1件: Cholinergic synapse Ezogabine 💬 Ezogabine 2件: 2, 144 💬
54 GABRQ 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
55 GABRQ 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Clobazam 💬 Clobazam 2件: 140, 144 💬
56 KCNQ5 💬 1件: Cholinergic synapse Ezogabine 💬 Ezogabine 2件: 2, 144 💬
57 SCN1A 💬 1件: Dopaminergic synapse Lamotrigine 💬 Lamotrigine 5件: 13, 34, 38, 114, 144 💬
58 SCN1A 💬 1件: Dopaminergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
59 SCN1A 💬 1件: Dopaminergic synapse Rufinamide 💬 Rufinamide 1件: 144 💬
60 SCN2A 💬 1件: Taste transduction Lamotrigine 💬 Lamotrigine 5件: 13, 34, 38, 114, 144 💬
61 SCN2A 💬 1件: Taste transduction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
62 SCN2A 💬 1件: Taste transduction Rufinamide 💬 Rufinamide 1件: 144 💬
63 SCN3A 💬 1件: Taste transduction Lamotrigine 💬 Lamotrigine 5件: 13, 34, 38, 114, 144 💬
64 SCN3A 💬 1件: Taste transduction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
65 SCN3A 💬 1件: Taste transduction Rufinamide 💬 Rufinamide 1件: 144 💬
66 SCN5A 💬 1件: Adrenergic signaling in cardiomyocytes Lamotrigine 💬 Lamotrigine 5件: 13, 34, 38, 114, 144 💬
67 SCN5A 💬 1件: Adrenergic signaling in cardiomyocytes Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
68 SCN5A 💬 1件: Adrenergic signaling in cardiomyocytes Rufinamide 💬 Rufinamide 1件: 144 💬
69 SCN9A 💬 1件: Taste transduction Lamotrigine 💬 Lamotrigine 5件: 13, 34, 38, 114, 144 💬
70 SCN9A 💬 1件: Taste transduction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
71 SCN9A 💬 1件: Taste transduction Rufinamide 💬 Rufinamide 1件: 144 💬
72 SLC6A4 💬 2件: Synaptic vesicle cycle, Serotonergic synapse Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
73 CA2 💬 7件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
74 CA4 💬 3件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
75 CACNA1C 💬 34件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
76 CACNA1D 💬 35件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
77 CACNA1F 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
78 CACNA1S 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
79 KCNQ4 💬 1件: Cholinergic synapse Ezogabine 💬 Ezogabine 2件: 2, 144 💬