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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

DHFR 💬

[5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...

Methotrexate 💬

Methotrexate

[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
84	Sarcoidosis
93	Primary biliary cholangitis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
172	Hypophosphatasia
256	Muscle glycogenosis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia
285	Fanconi anemia
286	Hereditary sideroblastic anemia
326	Osteopetrosis
331	Idiopathic multicentric castleman disease

DHFR2 💬

[5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...

Methotrexate 💬

Methotrexate

[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
84	Sarcoidosis
93	Primary biliary cholangitis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
172	Hypophosphatasia
256	Muscle glycogenosis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia
285	Fanconi anemia
286	Hereditary sideroblastic anemia
326	Osteopetrosis
331	Idiopathic multicentric castleman disease

IL1B 💬

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
50	Dermatomyositis
51	Scleroderma
58	Hypertrophic cardiomyopathy
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
164	Oculocutaneous albinism
222	Primary nephrotic syndrome
228	Bronchiolitis obliterans

IL1B 💬

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Rilonacept 💬

Rilonacept

[4] 51, 106, 107, 266 💬

IL1B 💬

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Canakinumab 💬

Canakinumab

[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
56	Behcet disease
84	Sarcoidosis
106	Cryopyrin-associated periodic syndrome
107	Juvenile idiopathic arthritis
108	TNF receptor-associated periodic syndrome
113	Muscular dystrophy
266	Familial mediterranean fever
267	Hyper-IgD syndrome
269	Pyogenic arthritis

IL1B 💬

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Gevokizumab 💬

Gevokizumab

[4] 41, 50, 56, 269 💬

IL6 💬

[51] EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor in ...

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
50	Dermatomyositis
51	Scleroderma
58	Hypertrophic cardiomyopathy
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
164	Oculocutaneous albinism
222	Primary nephrotic syndrome
228	Bronchiolitis obliterans