DDrare
Disease
Drug
Target Gene/Pathway
Contact
JA
Target Gene/Pathway
Pathway
/
Gene
Search
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Other
Search results
10
50
100
ALL
entries per page:
Showing 1 to 10 of 15 entries
Filter by
Reset
|
No.
KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
BRD4
💬
1. BRD4
×
Name
Full Name
BRD4
bromodomain containing 4
-
Apabetalone
Apabetalone
💬
1. BRD4
×
Name
Other Names
Apabetalone
Apabetalone (USAN/INN)
Apabetalone
[1]
86
86
💬
1. BRD4
×
Disease ID
Name
86
Pulmonary arterial hypertension
2
BCL2
💬
2. BCL2
×
Name
Full Name
BCL2
BCL2 apoptosis regulator
[43]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
Platinum drug resistance
,
NF-kappa B signaling pathway
,
HIF-1 signaling pathway
,
Sphingolipid signaling pathway
,
p53 signaling pathway
,
Autophagy - animal
,
Protein processing in endoplasmic reticulum
,
PI3K-Akt signaling pathway
,
Apoptosis
,
Apoptosis - multiple species
,
Necroptosis
,
Adrenergic signaling in cardiomyocytes
,
Hedgehog signaling pathway
,
Focal adhesion
,
NOD-like receptor signaling pathway
,
JAK-STAT signaling pathway
,
Neurotrophin signaling pathway
,
Cholinergic synapse
,
Estrogen signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
AGE-RAGE signaling pathway in diabetic complications
,
Amyotrophic lateral sclerosis
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Salmonella infection
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Measles
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Prostate cancer
,
Small cell lung cancer
,
Gastric cancer
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[43]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
Platinum drug resistance
,
NF-k
...
Venetoclax
Venetoclax
💬
2. BCL2
×
Name
Other Names
Venetoclax
Venetoclax (JAN/USAN/INN)
Venclexta (TN)
Venetoclax
[1]
28
28
💬
2. BCL2
×
Disease ID
Name
28
Systemic amyloidosis
3
BRD2
💬
3. BRD2
×
Name
Full Name
BRD2
bromodomain containing 2
-
Apabetalone
Apabetalone
💬
3. BRD2
×
Name
Other Names
Apabetalone
Apabetalone (USAN/INN)
Apabetalone
[1]
86
86
💬
3. BRD2
×
Disease ID
Name
86
Pulmonary arterial hypertension
4
BRAF
💬
4. BRAF
×
Name
Full Name
BRAF
B-Raf proto-oncogene, serine/threonine kinase
[44]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Rap1 signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
FoxO signaling pathway
,
mTOR signaling pathway
,
Vascular smooth muscle contraction
,
Focal adhesion
,
Natural killer cell mediated cytotoxicity
,
Long-term potentiation
,
Neurotrophin signaling pathway
,
Serotonergic synapse
,
Long-term depression
,
Regulation of actin cytoskeleton
,
Insulin signaling pathway
,
Progesterone-mediated oocyte maturation
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Alzheimer disease
,
Pathways of neurodegeneration - multiple diseases
,
Alcoholism
,
Hepatitis C
,
Hepatitis B
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Thyroid cancer
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Acute myeloid leukemia
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
[44]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Sorafenib
Sorafenib
💬
4. BRAF
×
Name
Other Names
Sorafenib
Sorafenib (USAN/INN)
Sorafenib
[2]
34
34
,
86
💬
4. BRAF
×
Disease ID
Name
34
Neurofibromatosis
86
Pulmonary arterial hypertension
5
BRAF
💬
5. BRAF
×
Name
Full Name
BRAF
B-Raf proto-oncogene, serine/threonine kinase
[44]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Rap1 signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
FoxO signaling pathway
,
mTOR signaling pathway
,
Vascular smooth muscle contraction
,
Focal adhesion
,
Natural killer cell mediated cytotoxicity
,
Long-term potentiation
,
Neurotrophin signaling pathway
,
Serotonergic synapse
,
Long-term depression
,
Regulation of actin cytoskeleton
,
Insulin signaling pathway
,
Progesterone-mediated oocyte maturation
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Alzheimer disease
,
Pathways of neurodegeneration - multiple diseases
,
Alcoholism
,
Hepatitis C
,
Hepatitis B
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Thyroid cancer
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Acute myeloid leukemia
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
[44]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Dabrafenib
Dabrafenib
💬
5. BRAF
×
Name
Other Names
Dabrafenib
Dabrafenib (USAN)
Dabrafenib
[1]
34
34
💬
5. BRAF
×
Disease ID
Name
34
Neurofibromatosis
6
BRDT
💬
6. BRDT
×
Name
Full Name
BRDT
bromodomain testis associated
-
Apabetalone
Apabetalone
💬
6. BRDT
×
Name
Other Names
Apabetalone
Apabetalone (USAN/INN)
Apabetalone
[1]
86
86
💬
6. BRDT
×
Disease ID
Name
86
Pulmonary arterial hypertension
7
BTK
💬
7. BTK
×
Name
Full Name
BTK
Bruton tyrosine kinase
[7]
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Epstein-Barr virus infection
,
Primary immunodeficiency
[7]
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor s
...
Ibrutinib
Ibrutinib
💬
7. BTK
×
Name
Other Names
Ibrutinib
Ibrutinib (JAN/USAN)
Imbruvica (TN)
Ibrutinib
[3]
28
28
,
60
,
61
💬
7. BTK
×
Disease ID
Name
28
Systemic amyloidosis
60
Aplastic anemia
61
Autoimmune hemolytic anemia
8
BTK
💬
8. BTK
×
Name
Full Name
BTK
Bruton tyrosine kinase
[7]
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Epstein-Barr virus infection
,
Primary immunodeficiency
[7]
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor s
...
Acalabrutinib
Acalabrutinib
💬
8. BTK
×
Name
Other Names
Acalabrutinib
Acalabrutinib (JAN/USAN/INN)
Calquence (TN)
Acalabrutinib
[2]
46
46
,
61
💬
8. BTK
×
Disease ID
Name
46
Malignant rheumatoid arthritis
61
Autoimmune hemolytic anemia
9
BTK
💬
9. BTK
×
Name
Full Name
BTK
Bruton tyrosine kinase
[7]
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Epstein-Barr virus infection
,
Primary immunodeficiency
[7]
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor s
...
Zanubrutinib
Zanubrutinib
💬
9. BTK
×
Name
Other Names
Zanubrutinib
Zanubrutinib (JAN/USAN/INN)
Brukinsa (TN)
Zanubrutinib
[5]
13
13
,
63
,
222
,
300
,
331
💬
9. BTK
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
63
Idiopathic thrombocytopenic purpura
222
Primary nephrotic syndrome
300
IgG4-related disease
331
Idiopathic multicentric castleman disease
10
BTK
💬
10. BTK
×
Name
Full Name
BTK
Bruton tyrosine kinase
[7]
NF-kappa B signaling pathway
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Epstein-Barr virus infection
,
Primary immunodeficiency
[7]
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Platelet activation
,
B cell receptor s
...
Fenebrutinib
Fenebrutinib
💬
10. BTK
×
Name
Other Names
Fenebrutinib
Fenebrutinib (USAN/INN)
Fenebrutinib
[1]
13
13
💬
10. BTK
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica