Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis
47	Buerger disease
51	Scleroderma
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
88	Chronic thromboembolic pulmonary hypertension
210	Single Ventricle
211	Hypoplastic left heart syndrome
212	Tricuspid atresia

2

[7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...

Ambrisentan 💬

[7] 51, 84, 85, 86, 88, 210, 211 💬

Disease ID	Name
51	Scleroderma
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
88	Chronic thromboembolic pulmonary hypertension
210	Single Ventricle
211	Hypoplastic left heart syndrome

3

[7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...

Sitaxentan 💬

[1] 86 💬

4

[7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis
47	Buerger disease
51	Scleroderma
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
88	Chronic thromboembolic pulmonary hypertension
210	Single Ventricle
211	Hypoplastic left heart syndrome
212	Tricuspid atresia

5

[7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...

Zibotentan 💬

[1] 51 💬

6

[7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...

Macitentan 💬

[5] 51, 85, 86, 88, 210 💬

7

[7] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...

Sparsentan 💬

[3] 66, 218, 222 💬

8

[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis
47	Buerger disease
51	Scleroderma
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
88	Chronic thromboembolic pulmonary hypertension
210	Single Ventricle
211	Hypoplastic left heart syndrome
212	Tricuspid atresia

9

[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis
47	Buerger disease
51	Scleroderma
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
88	Chronic thromboembolic pulmonary hypertension
210	Single Ventricle
211	Hypoplastic left heart syndrome
212	Tricuspid atresia

10

[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...

Macitentan 💬

[5] 51, 85, 86, 88, 210 💬

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