Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction

Aminophylline 💬

[1] 63 💬

2

[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction

Theophylline 💬

[2] 236, 299 💬

3

[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction

Theophylline 💬

[2] 236, 299 💬

4

[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction

Bucladesine 💬

[1] 246 💬

5

[4] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction

[1] 226 💬

6

[2] Nitrogen metabolism, Metabolic pathways

Acetazolamide 💬

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
86	Pulmonary arterial hypertension
90	Retinitis pigmentosa
115	Hereditary periodic paralysis
154	Epilepsy with continuous spikes and waves during slow sleep
155	Acquired aphasia with convulsive disorder
225	Congenital nephrogenic diabetes insipidus
230	Alveolar hypoventilation syndrome

7

[2] Nitrogen metabolism, Metabolic pathways

Dichlorphenamide 💬

[1] 114 💬

8

[2] Nitrogen metabolism, Metabolic pathways

Dorzolamide 💬

[1] 90 💬

9

[4] Tryptophan metabolism, Folate biosynthesis, Metabolic pathways, Serotonergic synapse

Telotristat 💬

[1] 97 💬

10

[9] Glycolysis / Gluconeogenesis, Fatty acid degradation, Tyrosine metabolism, Pyruvate metabolism, ...

Fomepizole 💬

[1] 301 💬

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