Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[3] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway

Dipyridamole 💬

[6] 46, 49, 51, 66, 96, 224 💬

2

[3] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway

[8] 2, 6, 21, 46, 78, 96, 97, 265 💬

3

[3] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway

Caffeine hydrate 💬

[8] 2, 6, 21, 46, 78, 96, 97, 265 💬

4

[3] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway

[7] 6, 51, 75, 84, 86, 113, 210 💬

5

[3] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway

Sildenafil 💬

[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬

Disease ID	Name
6	Parkinson disease
46	Malignant rheumatoid arthritis
50	Dermatomyositis
51	Scleroderma
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
90	Retinitis pigmentosa
113	Muscular dystrophy
210	Single Ventricle
211	Hypoplastic left heart syndrome
212	Tricuspid atresia
225	Congenital nephrogenic diabetes insipidus
226	Interstitial cystitis with Hunners ulcer
278	Huge lymphatic malformation with cervicofacial lesion
294	Congenital diaphragmatic hernia
299	Cystic fibrosis
301	Macular dystrophy

6

[3] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway

Vardenafil 💬

[3] 13, 86, 299 💬

7

[3] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway

[2] 86, 210 💬

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