Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	指定難病告示番号
1	Antifolate resistance 💬	2件: DHFR, DHFR2 💬	D00142 💬	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
2	Antifolate resistance 💬	1件: IL1B 💬	D09315 💬	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
3	Antifolate resistance 💬	1件: IL1B 💬	D09911 💬	Gevokizumab	4件: 41, 50, 56, 269 💬
4	Antifolate resistance 💬	1件: IL1B 💬	D06635 💬	Rilonacept	4件: 51, 106, 107, 266 💬
5	Antifolate resistance 💬	3件: IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
6	Antifolate resistance 💬	1件: IL6 💬	D12487 💬	Olokizumab	2件: 46, 96 💬
7	Antifolate resistance 💬	1件: IL6 💬	D09669 💬	Siltuximab	2件: 28, 331 💬
8	Antifolate resistance 💬	1件: IL6 💬	D10080 💬	Sirukumab	2件: 41, 46 💬
9	Antifolate resistance 💬	2件: IL6, TNF 💬	D08976 💬	Pomalidomide	5件: 28, 51, 85, 227, 331 💬
10	Antifolate resistance 💬	1件: NFKB1 💬	D01146 💬	Iguratimod	5件: 46, 51, 53, 271, 300 💬

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