Target Gene/Pathway Pathway / Gene


Search results


No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Acute myeloid leukemia 💬
[2] PML, RARA 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
2 Adherens junction 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
3 Adherens junction 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
4 Adipocytokine signaling pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
5 Adipocytokine signaling pathway 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
6 Adrenergic signaling in cardiomyocytes 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
7 AGE-RAGE signaling pathway in diabetic complications 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
8 Alcoholic liver disease 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
9 Alcoholism 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
10 Alcoholism 💬
[11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 D06320 💬 Vorinostat [2] 75, 96 💬
11 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
12 Aldosterone synthesis and secretion 💬
[1] CYP11A1 💬 D10950 💬 Levoketoconazole [1] 75 💬
13 Aldosterone synthesis and secretion 💬
[1] CYP11B2 💬 D11061 💬 Osilodrostat [1] 75 💬
14 Aldosterone synthesis and secretion 💬
[1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
15 Aldosterone-regulated sodium reabsorption 💬
[1] NR3C2 💬 D01115 💬 Eplerenone [4] 75, 113, 210, 215 💬
16 Amphetamine addiction 💬
[2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
17 AMPK signaling pathway 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
18 AMPK signaling pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
19 Amyotrophic lateral sclerosis 💬
[1] HDAC6 💬 D06320 💬 Vorinostat [2] 75, 96 💬
20 Apelin signaling pathway 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
21 Apelin signaling pathway 💬
[2] HDAC4, HDAC5 💬 D06320 💬 Vorinostat [2] 75, 96 💬
22 Apelin signaling pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
23 Autophagy - animal 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
24 Bile secretion 💬
[1] RXRA 💬 D03106 💬 Bexarotene [2] 13, 75 💬
25 Bladder cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
26 Bladder cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
27 Breast cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
28 Breast cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
29 Breast cancer 💬
[1] PGR 💬 D00585 💬 Mifepristone [1] 75 💬
30 Calcium signaling pathway 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
31 Calcium signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
32 Calcium signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
33 cAMP signaling pathway 💬
[2] CRHR1, CRHR2 💬 D03905 💬 Corticorelin [1] 75 💬
34 cAMP signaling pathway 💬
[2] CRHR1, CRHR2 💬 D03592 💬 Corticorelin ovine triflutate [1] 75 💬
35 cAMP signaling pathway 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
36 cAMP signaling pathway 💬
[1] GLP1R 💬 D06404 💬 Liraglutide [3]  6 , 75, 193 💬
37 cAMP signaling pathway 💬
[1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
38 cAMP signaling pathway 💬
[3] SSTR1, SSTR2, SSTR5 💬 D10147 💬 Pasireotide [3] 67, 74, 75 💬
39 cAMP signaling pathway 💬
[1] SSTR2 💬 D00442 💬 Octreotide [7] 67, 75, 84, 85, 89, 193, 227 💬
40 Cell cycle 💬
[3] HDAC1, HDAC2, HDAC8 💬 D06320 💬 Vorinostat [2] 75, 96 💬
41 Central carbon metabolism in cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
42 Central carbon metabolism in cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
43 cGMP-PKG signaling pathway 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
44 cGMP-PKG signaling pathway 💬
[1] PDE5A 💬 D02008 💬 Tadalafil [7]  6 , 51, 75, 84, 86, 113, 210 💬
45 Chemical carcinogenesis - reactive oxygen species 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
46 Chemical carcinogenesis - reactive oxygen species 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
47 Chemical carcinogenesis - receptor activation 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
48 Chemical carcinogenesis - receptor activation 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
49 Chemical carcinogenesis - receptor activation 💬
[1] PGR 💬 D00585 💬 Mifepristone [1] 75 💬
50 Chemical carcinogenesis - receptor activation 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
51 Choline metabolism in cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
52 Choline metabolism in cancer 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
53 Chronic myeloid leukemia 💬
[2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
54 Circadian rhythm 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
55 Cocaine addiction 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
56 Colorectal cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
57 Colorectal cancer 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
58 Complement and coagulation cascades 💬
[1] F2 💬 D09707 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
59 Complement and coagulation cascades 💬
[1] F2 💬 D07144 💬 Dabigatran etexilate [2] 51, 75 💬
60 Complement and coagulation cascades 💬
[1] F8 💬 D00291 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
61 Coronavirus disease - COVID-19 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
62 Coronavirus disease - COVID-19 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
63 Coronavirus disease - COVID-19 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
64 Coronavirus disease - COVID-19 💬
[1] F2 💬 D09707 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
65 Coronavirus disease - COVID-19 💬
[1] F2 💬 D07144 💬 Dabigatran etexilate [2] 51, 75 💬
66 Cortisol synthesis and secretion 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
67 Cortisol synthesis and secretion 💬
[3] CYP11A1, CYP11B1, CYP17A1 💬 D10950 💬 Levoketoconazole [1] 75 💬
68 Cortisol synthesis and secretion 💬
[1] CYP11B1 💬 D00410 💬 Metyrapone [1] 75 💬
69 Cortisol synthesis and secretion 💬
[1] CYP17A1 💬 D00351 💬 Ketoconazole [3]  8 , 13, 75 💬
70 Cortisol synthesis and secretion 💬
[1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
71 Cushing syndrome 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
72 Cushing syndrome 💬
[2] CRHR1, CRHR2 💬 D03905 💬 Corticorelin [1] 75 💬
73 Cushing syndrome 💬
[2] CRHR1, CRHR2 💬 D03592 💬 Corticorelin ovine triflutate [1] 75 💬
74 Cushing syndrome 💬
[3] CYP11A1, CYP11B1, CYP17A1 💬 D10950 💬 Levoketoconazole [1] 75 💬
75 Cushing syndrome 💬
[1] CYP11B1 💬 D00410 💬 Metyrapone [1] 75 💬
76 Cushing syndrome 💬
[1] CYP17A1 💬 D00351 💬 Ketoconazole [3]  8 , 13, 75 💬
77 Cushing syndrome 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
78 Cushing syndrome 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
79 Cushing syndrome 💬
[1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
80 Cytokine-cytokine receptor interaction 💬
[1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
81 Diabetic cardiomyopathy 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
82 Dopaminergic synapse 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
83 EGFR tyrosine kinase inhibitor resistance 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
84 EGFR tyrosine kinase inhibitor resistance 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
85 Endocrine resistance 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
86 Endocrine resistance 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
87 Endocytosis 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
88 Endocytosis 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
89 Endocytosis 💬
[1] PML 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
90 Endometrial cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
91 Endometrial cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
92 Epithelial cell signaling in Helicobacter pylori infection 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
93 Epithelial cell signaling in Helicobacter pylori infection 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
94 Epstein-Barr virus infection 💬
[2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
95 ErbB signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
96 ErbB signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
97 Estrogen signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
98 Estrogen signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
99 Estrogen signaling pathway 💬
[1] PGR 💬 D00585 💬 Mifepristone [1] 75 💬
100 Estrogen signaling pathway 💬
[1] RARA 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
101 Fluid shear stress and atherosclerosis 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
102 Focal adhesion 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
103 Focal adhesion 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
104 FoxO signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
105 FoxO signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
106 FoxO signaling pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
107 GABAergic synapse 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00225 💬 Alprazolam [2]  8 , 75 💬
108 GABAergic synapse 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
109 Gap junction 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
110 Gap junction 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
111 Gap junction 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
112 Gastric acid secretion 💬
[1] SSTR2 💬 D00442 💬 Octreotide [7] 67, 75, 84, 85, 89, 193, 227 💬
113 Gastric acid secretion 💬
[1] SSTR2 💬 D10147 💬 Pasireotide [3] 67, 74, 75 💬
114 Gastric cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
115 Gastric cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
116 Gastric cancer 💬
[1] RARB 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
117 Gastric cancer 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
118 Glioma 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
119 Glioma 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
120 Glucagon signaling pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
121 GnRH signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
122 GnRH signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
123 Growth hormone synthesis, secretion and action 💬
[4] SSTR1, SSTR2, SSTR3, SSTR5 💬 D10147 💬 Pasireotide [3] 67, 74, 75 💬
124 Growth hormone synthesis, secretion and action 💬
[1] SSTR2 💬 D00442 💬 Octreotide [7] 67, 75, 84, 85, 89, 193, 227 💬
125 Hepatitis C 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
126 Hepatitis C 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
127 Hepatitis C 💬
[1] RXRA 💬 D03106 💬 Bexarotene [2] 13, 75 💬
128 Hepatocellular carcinoma 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
129 Hepatocellular carcinoma 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
130 Herpes simplex virus 1 infection 💬
[1] PML 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
131 HIF-1 signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
132 HIF-1 signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
133 Human cytomegalovirus infection 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
134 Human cytomegalovirus infection 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
135 Human papillomavirus infection 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
136 Human papillomavirus infection 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
137 Human papillomavirus infection 💬
[2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
138 Huntington disease 💬
[2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
139 Huntington disease 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
140 Hypertrophic cardiomyopathy 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
141 Influenza A 💬
[1] PML 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
142 Insulin resistance 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
143 Insulin secretion 💬
[1] GLP1R 💬 D06404 💬 Liraglutide [3]  6 , 75, 193 💬
144 Insulin signaling pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
145 JAK-STAT signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
146 JAK-STAT signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
147 JAK-STAT signaling pathway 💬
[1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
148 Lipid and atherosclerosis 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
149 Lipid and atherosclerosis 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
150 Long-term depression 💬
[1] CRHR1 💬 D03905 💬 Corticorelin [1] 75 💬
151 Long-term depression 💬
[1] CRHR1 💬 D03592 💬 Corticorelin ovine triflutate [1] 75 💬
152 Longevity regulating pathway 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
153 Longevity regulating pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
154 Longevity regulating pathway - multiple species 💬
[2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
155 Longevity regulating pathway - multiple species 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
156 MAPK signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
157 MAPK signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
158 Melanoma 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
159 Melanoma 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
160 Metabolic pathways 💬
[3] CYP11A1, CYP11B1, CYP17A1 💬 D10950 💬 Levoketoconazole [1] 75 💬
161 Metabolic pathways 💬
[1] CYP11B1 💬 D00410 💬 Metyrapone [1] 75 💬
162 Metabolic pathways 💬
[1] CYP11B2 💬 D11061 💬 Osilodrostat [1] 75 💬
163 Metabolic pathways 💬
[1] CYP17A1 💬 D00351 💬 Ketoconazole [3]  8 , 13, 75 💬
164 Metabolic pathways 💬
[1] PDE5A 💬 D02008 💬 Tadalafil [7]  6 , 51, 75, 84, 86, 113, 210 💬
165 MicroRNAs in cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
166 MicroRNAs in cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
167 MicroRNAs in cancer 💬
[4] HDAC1, HDAC2, HDAC4, HDAC5 💬 D06320 💬 Vorinostat [2] 75, 96 💬
168 Morphine addiction 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00225 💬 Alprazolam [2]  8 , 75 💬
169 Morphine addiction 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
170 mTOR signaling pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
171 Neuroactive ligand-receptor interaction 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
172 Neuroactive ligand-receptor interaction 💬
[1] AVPR2 💬 D00291 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
173 Neuroactive ligand-receptor interaction 💬
[2] CRHR1, CRHR2 💬 D03905 💬 Corticorelin [1] 75 💬
174 Neuroactive ligand-receptor interaction 💬
[2] CRHR1, CRHR2 💬 D03592 💬 Corticorelin ovine triflutate [1] 75 💬
175 Neuroactive ligand-receptor interaction 💬
[2] DRD2, PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
176 Neuroactive ligand-receptor interaction 💬
[1] F2 💬 D09707 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
177 Neuroactive ligand-receptor interaction 💬
[1] F2 💬 D07144 💬 Dabigatran etexilate [2] 51, 75 💬
178 Neuroactive ligand-receptor interaction 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00225 💬 Alprazolam [2]  8 , 75 💬
179 Neuroactive ligand-receptor interaction 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
180 Neuroactive ligand-receptor interaction 💬
[1] GLP1R 💬 D06404 💬 Liraglutide [3]  6 , 75, 193 💬
181 Neuroactive ligand-receptor interaction 💬
[1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
182 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D00088 💬 Hydrocortisone [10]  6 , 41, 46, 53, 75, 78, 81, 83, 97, 299 💬
183 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D00585 💬 Mifepristone [1] 75 💬
184 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D00472 💬 Prednisolone [42]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
185 Neuroactive ligand-receptor interaction 💬
[1] NR3C1 💬 D11336 💬 Relacorilant [1] 75 💬
186 Neuroactive ligand-receptor interaction 💬
[4] SSTR1, SSTR2, SSTR3, SSTR5 💬 D10147 💬 Pasireotide [3] 67, 74, 75 💬
187 Neuroactive ligand-receptor interaction 💬
[1] SSTR2 💬 D00442 💬 Octreotide [7] 67, 75, 84, 85, 89, 193, 227 💬
188 Neutrophil extracellular trap formation 💬
[11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 D06320 💬 Vorinostat [2] 75, 96 💬
189 Nicotine addiction 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00225 💬 Alprazolam [2]  8 , 75 💬
190 Nicotine addiction 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
191 Non-alcoholic fatty liver disease 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
192 Non-alcoholic fatty liver disease 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
193 Non-alcoholic fatty liver disease 💬
[1] RXRA 💬 D03106 💬 Bexarotene [2] 13, 75 💬
194 Non-small cell lung cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
195 Non-small cell lung cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
196 Non-small cell lung cancer 💬
[1] RARB 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
197 Non-small cell lung cancer 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
198 Notch signaling pathway 💬
[2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
199 Oocyte meiosis 💬
[1] PGR 💬 D00585 💬 Mifepristone [1] 75 💬
200 Osteoclast differentiation 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
201 Ovarian steroidogenesis 💬
[2] CYP11A1, CYP17A1 💬 D10950 💬 Levoketoconazole [1] 75 💬
202 Ovarian steroidogenesis 💬
[1] CYP17A1 💬 D00351 💬 Ketoconazole [3]  8 , 13, 75 💬
203 Oxytocin signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
204 Oxytocin signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
205 Oxytocin signaling pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
206 Pancreatic cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
207 Pancreatic cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
208 Parathyroid hormone synthesis, secretion and action 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
209 Parathyroid hormone synthesis, secretion and action 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
210 Parathyroid hormone synthesis, secretion and action 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
211 Parkinson disease 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
212 Pathogenic Escherichia coli infection 💬
[1] F2 💬 D09707 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
213 Pathogenic Escherichia coli infection 💬
[1] F2 💬 D07144 💬 Dabigatran etexilate [2] 51, 75 💬
214 Pathways in cancer 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
215 Pathways in cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
216 Pathways in cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
217 Pathways in cancer 💬
[1] F2 💬 D09707 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
218 Pathways in cancer 💬
[1] F2 💬 D07144 💬 Dabigatran etexilate [2] 51, 75 💬
219 Pathways in cancer 💬
[2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
220 Pathways in cancer 💬
[3] PML, RARA, RARB 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
221 Pathways in cancer 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
222 Pathways in cancer 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
223 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
224 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
225 Phospholipase D signaling pathway 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
226 Phospholipase D signaling pathway 💬
[1] AVPR2 💬 D00291 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
227 Phospholipase D signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
228 Phospholipase D signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
229 Phospholipase D signaling pathway 💬
[1] F2 💬 D09707 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
230 Phospholipase D signaling pathway 💬
[1] F2 💬 D07144 💬 Dabigatran etexilate [2] 51, 75 💬
231 PI3K-Akt signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
232 PI3K-Akt signaling pathway 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
233 PI3K-Akt signaling pathway 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
234 PI3K-Akt signaling pathway 💬
[1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
235 PI3K-Akt signaling pathway 💬
[1] RXRA 💬 D03106 💬 Bexarotene [2] 13, 75 💬
236 Platelet activation 💬
[1] F2 💬 D09707 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
237 Platelet activation 💬
[1] F2 💬 D07144 💬 Dabigatran etexilate [2] 51, 75 💬
238 Platinum drug resistance 💬
[1] ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
239 PPAR signaling pathway 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
240 PPAR signaling pathway 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
241 Progesterone-mediated oocyte maturation 💬
[1] PGR 💬 D00585 💬 Mifepristone [1] 75 💬
242 Prolactin signaling pathway 💬
[1] CYP17A1 💬 D00351 💬 Ketoconazole [3]  8 , 13, 75 💬
243 Prolactin signaling pathway 💬
[1] CYP17A1 💬 D10950 💬 Levoketoconazole [1] 75 💬
244 Prolactin signaling pathway 💬
[1] PRL 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
245 Prostate cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
246 Prostate cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
247 Protein digestion and absorption 💬
[1] DPP4 💬 D08516 💬 Sitagliptin [4]  6 , 75, 233, 299 💬
248 Proteoglycans in cancer 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
249 Proteoglycans in cancer 💬
[2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
250 Purine metabolism 💬
[1] PDE5A 💬 D02008 💬 Tadalafil [7]  6 , 51, 75, 84, 86, 113, 210 💬
251 Rap1 signaling pathway 💬
[1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
252 Rap1 signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
253 Rap1 signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
254 Ras signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
255 Ras signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
256 Regulation of actin cytoskeleton 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
257 Regulation of actin cytoskeleton 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
258 Regulation of actin cytoskeleton 💬
[1] F2 💬 D09707 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
259 Regulation of actin cytoskeleton 💬
[1] F2 💬 D07144 💬 Dabigatran etexilate [2] 51, 75 💬
260 Relaxin signaling pathway 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
261 Relaxin signaling pathway 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
262 Renin secretion 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
263 Renin-angiotensin system 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
264 Retrograde endocannabinoid signaling 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00225 💬 Alprazolam [2]  8 , 75 💬
265 Retrograde endocannabinoid signaling 💬
[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
266 Serotonergic synapse 💬
[3] GABRB1, GABRB2, GABRB3 💬 D00225 💬 Alprazolam [2]  8 , 75 💬
267 Serotonergic synapse 💬
[3] GABRB1, GABRB2, GABRB3 💬 D00549 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
268 Shigellosis 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
269 Shigellosis 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
270 Small cell lung cancer 💬
[1] RARB 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
271 Small cell lung cancer 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
272 Steroid hormone biosynthesis 💬
[3] CYP11A1, CYP11B1, CYP17A1 💬 D10950 💬 Levoketoconazole [1] 75 💬
273 Steroid hormone biosynthesis 💬
[1] CYP11B1 💬 D00410 💬 Metyrapone [1] 75 💬
274 Steroid hormone biosynthesis 💬
[1] CYP11B2 💬 D11061 💬 Osilodrostat [1] 75 💬
275 Steroid hormone biosynthesis 💬
[1] CYP17A1 💬 D00351 💬 Ketoconazole [3]  8 , 13, 75 💬
276 Taste transduction 💬
[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D00225 💬 Alprazolam [2]  8 , 75 💬
277 Taste transduction 💬
[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D00549 💬 Propofol [9]  6 , 21, 22, 34, 46, 70, 75, 98, 296 💬
278 Th17 cell differentiation 💬
[1] RARA 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
279 Th17 cell differentiation 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
280 Thermogenesis 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
281 Thermogenesis 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
282 Thyroid cancer 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
283 Thyroid cancer 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
284 Thyroid hormone signaling pathway 💬
[3] HDAC1, HDAC2, HDAC3 💬 D06320 💬 Vorinostat [2] 75, 96 💬
285 Thyroid hormone signaling pathway 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
286 Tight junction 💬
[1] ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
287 Tight junction 💬
[2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
288 Transcriptional misregulation in cancer 💬
[2] HDAC1, HDAC2 💬 D06320 💬 Vorinostat [2] 75, 96 💬
289 Transcriptional misregulation in cancer 💬
[2] PML, RARA 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
290 Transcriptional misregulation in cancer 💬
[1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
291 Transcriptional misregulation in cancer 💬
[3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
292 Ubiquitin mediated proteolysis 💬
[1] PML 💬 D00094 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬
293 Vascular smooth muscle contraction 💬
[1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
294 Vasopressin-regulated water reabsorption 💬
[1] AVPR2 💬 D00291 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
295 Viral carcinogenesis 💬
[11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 D06320 💬 Vorinostat [2] 75, 96 💬