Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Fluid shear stress and atherosclerosis 💬	[1] ACVR2A 💬	D09670 💬	Sotatercept	[2] 86, 284 💬
2	Fluid shear stress and atherosclerosis 💬	[2] ACVR2A, ACVR2B 💬	D10620 💬	Bimagrumab	[1] 15 💬
3	Fluid shear stress and atherosclerosis 💬	[1] ACVR2B 💬	D11701 💬	Luspatercept	[1] 60 💬
4	Fluid shear stress and atherosclerosis 💬	[1] BCL2 💬	D10679 💬	Venetoclax	[1] 28 💬
5	Fluid shear stress and atherosclerosis 💬	[4] CCL2, IL1A, IL1B, TNF 💬	D01583 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
6	Fluid shear stress and atherosclerosis 💬	[1] HMOX1 💬	D05922 💬	Stannsoporfin	[1] 254 💬
7	Fluid shear stress and atherosclerosis 💬	[1] IFNG 💬	D11120 💬	Emapalumab	[3] 49, 65, 107 💬
8	Fluid shear stress and atherosclerosis 💬	[1] IFNG 💬	D04242 💬	Fontolizumab	[1] 46 💬
9	Fluid shear stress and atherosclerosis 💬	[1] IL1A 💬	D11253 💬	Bermekimab	[1] 51 💬
10	Fluid shear stress and atherosclerosis 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬

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