Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 cGMP-PKG signaling pathway 💬
 [2] ADORA1, ADORA3 💬 D00045 💬 Adenosine [3] 13, 58, 65 💬
2 cGMP-PKG signaling pathway 💬
 [2] ADORA1, ADORA3 💬 D02769 💬 Adenosine phosphate [1] 46 💬
3 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D00227 💬 Aminophylline [1] 63 💬
4 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D00371 💬 Theophylline [2] 236, 299 💬
5 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D06103 💬 Theophylline [2] 236, 299 💬
6 cGMP-PKG signaling pathway 💬
 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 D00528 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
7 cGMP-PKG signaling pathway 💬
 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 D01453 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
8 cGMP-PKG signaling pathway 💬
 [1] ADORA3 💬 D10971 💬 Piclidenoson [1] 46 💬
9 cGMP-PKG signaling pathway 💬
 [1] ADRA1A 💬 D07124 💬 Alfuzosin [1] 13 💬
10 cGMP-PKG signaling pathway 💬
 [1] ADRA1A 💬 D01965 💬 Silodosin [2]  6 , 13 💬
11 cGMP-PKG signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin [2] 57, 67 💬
12 cGMP-PKG signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08220 💬 Midodrine [3]  6 , 17, 58 💬
13 cGMP-PKG signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00454 💬 Olanzapine [2]  2 ,  8  💬
14 cGMP-PKG signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine [1] 22 💬
15 cGMP-PKG signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08560 💬 Tamsulosin [1] 13 💬
16 cGMP-PKG signaling pathway 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08569 💬 Terazosin [1]  6  💬
17 cGMP-PKG signaling pathway 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C 💬 D08207 💬 Methylergometrine [1] 280 💬
18 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D02349 💬 Dipivefrin [1]  6  💬
19 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D01277 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬
20 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D00124 💬 Ephedrine [1] 11 💬
21 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D00095 💬 Epinephrine [3] 46, 70, 96 💬
22 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine [2] 22, 296 💬
23 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 D08449 💬 Pseudoephedrine [1] 17 💬
24 cGMP-PKG signaling pathway 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00255 💬 Carvedilol [4] 57, 86, 113, 210 💬
25 cGMP-PKG signaling pathway 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNJ8 💬 D02910 💬 Amiodarone [2] 28, 127 💬
26 cGMP-PKG signaling pathway 💬
 [1] ADRA2A 💬 D08031 💬 Guanfacine [1] 193 💬
27 cGMP-PKG signaling pathway 💬
 [1] ADRA2A 💬 D00560 💬 Pimozide [1]  2  💬
28 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D07461 💬 Apraclonidine [1] 11 💬
29 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D07540 💬 Brimonidine [2] 13, 90 💬
30 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D00270 💬 Chlorpromazine [1] 254 💬
31 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D00281 💬 Clonidine [4]  6 , 65, 70, 78 💬
32 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D00283 💬 Clozapine [1]  6  💬
33 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D00514 💬 Dexmedetomidine [14]  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
34 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D04375 💬 Guanabenz [2]  2 , 13 💬
35 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D08482 💬 Rilmenidine [1]  8  💬
36 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D08611 💬 Tizanidine [1] 13 💬
37 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 D08685 💬 Yohimbine [1]  6  💬
38 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D00235 💬 Atenolol [1] 167 💬
39 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D02342 💬 Bisoprolol [4] 58, 67, 86, 113 💬
40 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
41 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [4] 57, 58, 86, 215 💬
42 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D07916 💬 Esmolol [1] 58 💬
43 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
44 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 D05127 💬 Nebivolol [4] 17, 85, 113, 167 💬
45 cGMP-PKG signaling pathway 💬
 [2] ADRB1, ADRB2 💬 D00432 💬 Nadolol [1]  6  💬
46 cGMP-PKG signaling pathway 💬
 [2] ADRB1, ADRB2 💬 D00378 💬 Timolol [2] 157, 227 💬
47 cGMP-PKG signaling pathway 💬
 [2] ADRB1, ADRB2 💬 D08600 💬 Timolol [2] 157, 227 💬
48 cGMP-PKG signaling pathway 💬
 [3] ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
49 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 D07713 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬
50 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 D07990 💬 Formoterol [3] 85, 228, 299 💬
51 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 D08092 💬 Isoxsuprine [1] 13 💬
52 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 D08124 💬 Levosalbutamol [1] 49 💬
53 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 D02147 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬
54 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 D05792 💬 Salmeterol [1] 299 💬
55 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 D08570 💬 Terbutaline [1] 118 💬
56 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 D02151 💬 Tulobuterol [1]  6  💬
57 cGMP-PKG signaling pathway 💬
 [1] ADRB3 💬 D09535 💬 Mirabegron [4]  6 , 13, 53, 226 💬
58 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00150 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
59 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D02014 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
60 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00522 💬 Candesartan [2] 58, 67 💬
61 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00626 💬 Candesartan cilexetil [1] 67 💬
62 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
63 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
64 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00627 💬 Telmisartan [2] 66, 67 💬
65 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
66 cGMP-PKG signaling pathway 💬
 [2] AGTR1, EDNRA 💬 D11776 💬 Sparsentan [3] 66, 218, 222 💬
67 cGMP-PKG signaling pathway 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00297 💬 Digitoxin [1] 299 💬
68 cGMP-PKG signaling pathway 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00298 💬 Digoxin [3]  8 , 46, 210 💬
69 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
70 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine [1] 67 💬
71 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
72 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine [1]  6  💬
73 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine [2] 70, 86 💬
74 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine [2] 50, 81 💬
75 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine [1] 90 💬
76 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline [2] 58, 272 💬
77 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine [1] 226 💬
78 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
79 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil [4] 58, 96, 140, 167 💬
80 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 D07077 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
81 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 D07171 💬 Sitaxentan [1] 86 💬
82 cGMP-PKG signaling pathway 💬
 [1] EDNRA 💬 D07741 💬 Zibotentan [1] 51 💬
83 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
84 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
85 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D10135 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
86 cGMP-PKG signaling pathway 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 D00517 💬 Amyl Nitrite [1] 58 💬
87 cGMP-PKG signaling pathway 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 D09572 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
88 cGMP-PKG signaling pathway 💬
 [1] INSR 💬 D04539 💬 Insulin detemir [1] 299 💬
89 cGMP-PKG signaling pathway 💬
 [1] INSR 💬 D03250 💬 Insulin glargine [1] 299 💬
90 cGMP-PKG signaling pathway 💬
 [1] INSR 💬 D03230 💬 Insulin human [2] 96, 156 💬
91 cGMP-PKG signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
92 cGMP-PKG signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
93 cGMP-PKG signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib [1] 34 💬
94 cGMP-PKG signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
95 cGMP-PKG signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
96 cGMP-PKG signaling pathway 💬
 [1] MYH7 💬 D12265 💬 Mavacamten [1] 58 💬
97 cGMP-PKG signaling pathway 💬
 [1] NPR1 💬 D05147 💬 Nesiritide [2] 46, 58 💬
98 cGMP-PKG signaling pathway 💬
 [2] NPR1, NPR2 💬 D04051 💬 Erythrityl tetranitrate [1] 46 💬
99 cGMP-PKG signaling pathway 💬
 [1] NPR2 💬 D11190 💬 Vosoritide [1] 276 💬
100 cGMP-PKG signaling pathway 💬
 [1] OPRD1 💬 D08144 💬 Loperamide [2] 13, 97 💬
101 cGMP-PKG signaling pathway 💬
 [1] OPRD1 💬 D08246 💬 Nalbuphine [1] 85 💬
102 cGMP-PKG signaling pathway 💬
 [1] OPRD1 💬 D05111 💬 Nalmefene [1]  6  💬
103 cGMP-PKG signaling pathway 💬
 [1] OPRD1 💬 D08249 💬 Naloxone [2]  6 , 226 💬
104 cGMP-PKG signaling pathway 💬
 [1] OPRD1 💬 D05113 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
105 cGMP-PKG signaling pathway 💬
 [1] OPRD1 💬 D05312 💬 Oxycodone [5]  6 , 13, 70, 226, 298 💬
106 cGMP-PKG signaling pathway 💬
 [3] PDE2A, PDE3A, PDE3B 💬 D07546 💬 Bucladesine [1] 246 💬
107 cGMP-PKG signaling pathway 💬
 [3] PDE2A, PDE3A, PDE3B 💬 D07961 💬 Flavoxate [1] 226 💬
108 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 D01896 💬 Cilostazol [3] 46, 51, 70 💬
109 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 D01385 💬 Ibudilast [2]  2 , 13 💬
110 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 D04720 💬 Levosimendan [1]  2  💬
111 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 D00417 💬 Milrinone [1] 294 💬
112 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 D00302 💬 Dipyridamole [6] 46, 49, 51, 66, 96, 224 💬
113 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 D08514 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
114 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 D02008 💬 Tadalafil [7]  6 , 51, 75, 84, 86, 113, 210 💬
115 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 D10027 💬 Udenafil [2] 86, 210 💬
116 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 D08668 💬 Vardenafil [3] 13, 86, 299 💬
117 cGMP-PKG signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
118 cGMP-PKG signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
119 cGMP-PKG signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
120 cGMP-PKG signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
121 cGMP-PKG signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [2] 49, 222 💬
122 cGMP-PKG signaling pathway 💬
 [1] PRKCE 💬 D09671 💬 Sotrastaurin [1] 97 💬
123 cGMP-PKG signaling pathway 💬
 [1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
124 cGMP-PKG signaling pathway 💬
 [2] ROCK1, ROCK2 💬 D07941 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬
125 cGMP-PKG signaling pathway 💬
 [1] ROCK2 💬 D11815 💬 Belumosudil [2] 51, 85 💬