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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
12% sodium chondroitin sulfate2件: Chondroitin sulfate,
Sulfate ion		---1件: 226
25% lidocaine/5 mg/ml 0.02% estradiol compound cream2件: Estradiol,
Lidocaine		11件: D00105 ,
D00358 ,
D01413 ,
D01617 ,
D01953 ,
D02086 ,
D04061 ,
D04063 ,
D04064 ,
D04065 ,
D08127 		7件: ESR1,
ESR2,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		13件: Adrenergic signaling in cardiomyocytes, Breast cancer, Chemical carcinogenesis - receptor activation, Dopaminergic synapse, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Taste transduction, Thyroid hormone signaling pathway 💬1件: 226
3Adalimumab1件: Adalimumab1件: D02597 1件: TNF 💬67件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271
4AGN 203818----1件: 226
5Alkalinized Lidocaine-Heparin2件: Heparin,
Lidocaine		4件: D00358 ,
D02086 ,
D07510 ,
D08127 		6件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A,
SERPINC1 💬		4件: Adrenergic signaling in cardiomyocytes, Complement and coagulation cascades, Dopaminergic synapse, Taste transduction 💬1件: 226
6AlloRx----8件: 2, 6, 13, 46, 51, 85, 90, 226
7Aloe1件: Aloe vera leaf---2件: 97, 226
8Aloe vera1件: Aloe vera leaf---3件: 53, 97, 226
9Amitriptyline1件: Amitriptyline2件: D00809 ,
D07448 		2件: SLC6A2,
SLC6A4 💬		2件: Serotonergic synapse, Synaptic vesicle cycle 💬4件: 78, 97, 226, 299
10AQX-11251件: AQX-1125---1件: 226
11AQX-1125 100 mg1件: AQX-1125---1件: 226
12AQX-1125 200 mg1件: AQX-1125---1件: 226
13ASP3652----1件: 226
14ASP6294----1件: 226
15Bladder instillation with heparin/ lidocaine2件: Heparin,
Lidocaine		4件: D00358 ,
D02086 ,
D07510 ,
D08127 		6件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A,
SERPINC1 💬		4件: Adrenergic signaling in cardiomyocytes, Complement and coagulation cascades, Dopaminergic synapse, Taste transduction 💬1件: 226
16Bladder instillation WITH triamcinolone acetonide1件: Triamcinolone5件: D00385 ,
D00983 ,
D00984 ,
D00985 ,
D06216 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 226
17Bladder instillation WITHOUT triamcinolone acetonide1件: Triamcinolone5件: D00385 ,
D00983 ,
D00984 ,
D00985 ,
D06216 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬1件: 226
18Bladder Instillations----1件: 226
19Botox1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬6件: 2, 6, 13, 51, 149, 226
20BOTOX 100U in normal saline1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬1件: 226
21BOTOX 200U in normal saline1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬1件: 226
22Botulinum Neurotoxin----1件: 226
23Botulinum toxin A1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬4件: 13, 51, 149, 226
24Buckwheat1件: Buckwheat---1件: 226
25Bupivacaine1件: Bupivacaine2件: D01450 ,
D07552 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬8件: 46, 51, 53, 70, 96, 168, 226, 298
26Bupivacaine, triamcinolone, and heparin (BTH)3件: Bupivacaine,
Heparin,
Triamcinolone		8件: D00385 ,
D00983 ,
D00984 ,
D00985 ,
D01450 ,
D06216 ,
D07510 ,
D07552 		7件: NR3C1,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A,
SERPINC1 💬		5件: Adrenergic signaling in cardiomyocytes, Complement and coagulation cascades, Dopaminergic synapse, Neuroactive ligand-receptor interaction, Taste transduction 💬1件: 226
27Cannabidiol1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬18件: 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
28Cannabidiol vaginal suppository1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬1件: 226
29Capsaicin1件: Capsaicin1件: D00250 1件: TRPV1 💬2件: Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬5件: 2, 6, 19, 86, 226
30Certolizumab Pegol1件: Certolizumab pegol1件: D03441 1件: TNF 💬67件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬8件: 37, 46, 49, 96, 97, 107, 226, 271
31Chondroitin sulfate2件: Chondroitin sulfate,
Sulfate ion		---2件: 96, 226
32Ciclosporin1件: Cyclosporine1件: D00184 5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬13件: 26, 46, 49, 50, 53, 55, 60, 61, 97, 222, 226, 228, 269
33Ciklosporin----1件: 226
34Coconut1件: Coconut---3件: 13, 53, 226
35Coconut oil2件: Coconut,
Coconut oil		1件: D05326 --2件: 13, 226
36Combination Product: Hyperbaric Oxygen Therapy-1件: Oxygen1件: D00003 --1件: 226
37Cyclosporine1件: Cyclosporine1件: D00184 5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬37件: 11, 19, 20, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 107, 162, 164, 222, 226, 228, 234, 283, 284, 285, 302
38Desert Harvest Aloe Vera Capsules1件: Aloe vera leaf---1件: 226
39DEXMEDETOMIDINE1件: Dexmedetomidine2件: D00514 ,
D01205 		3件: ADRA2A,
ADRA2B,
ADRA2C 💬		2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
40Dextrose1件: Dextrose, unspecified form---5件: 56, 60, 65, 70, 226
41Dimethyl sulfoxide1件: Dimethyl sulfoxide1件: D01043 --1件: 226
42Dimethyl sulfoxide (DMSO)1件: Dimethyl sulfoxide1件: D01043 --1件: 226
43DMSO1件: Dimethyl sulfoxide1件: D01043 --1件: 226
44DMSO cocktail1件: Dimethyl sulfoxide1件: D01043 --1件: 226
45ERB-041----3件: 46, 96, 226
46Estradiol1件: Estradiol8件: D00105 ,
D01413 ,
D01617 ,
D01953 ,
D04061 ,
D04063 ,
D04064 ,
D04065 		2件: ESR1,
ESR2 💬		10件: Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬7件: 13, 46, 49, 65, 76, 226, 299
47Flavoxate1件: Flavoxate2件: D00718 ,
D07961 		16件: PDE10A,
PDE11A,
PDE1A,
PDE1B,
PDE1C,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE7A,
PDE7B,
PDE8A,
PDE8B 💬		18件: Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, Taste transduction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
48Fospropofol1件: Fospropofol---1件: 226
49Fospropofol (Lusedra®) 101件: Fospropofol---1件: 226
50Fospropofol (Lusedra®) 121件: Fospropofol---1件: 226
51Fospropofol (Lusedra®) 6.51件: Fospropofol---1件: 226
52Fremanezumab1件: Fremanezumab1件: D11055 1件: CALCA 💬2件: Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction 💬2件: 124, 226
53Gefapixant1件: Gefapixant1件: D11349 1件: P2RX3 💬3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Taste transduction 💬2件: 85, 226
54GLYCINE1件: Glycine1件: D00011 --5件: 35, 60, 86, 226, 299
55Gralise----2件: 97, 226
56Heparin1件: Heparin1件: D07510 1件: SERPINC1 💬1件: Complement and coagulation cascades 💬12件: 47, 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317
57Heparin & Alkalinized Lidocaine Bladder Instillation2件: Heparin,
Lidocaine		4件: D00358 ,
D02086 ,
D07510 ,
D08127 		6件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A,
SERPINC1 💬		4件: Adrenergic signaling in cardiomyocytes, Complement and coagulation cascades, Dopaminergic synapse, Taste transduction 💬1件: 226
58High Density Surface Electromyographic, precision botulinum neurotoxin injection guidance medical device----1件: 226
59Hyaluronic acid1件: Hyaluronic acid1件: D08043 --5件: 46, 53, 70, 226, 231
60Hyaluronic Acid and Chondroitin Sulfate3件: Chondroitin sulfate,
Hyaluronic acid,
Sulfate ion		1件: D08043 --1件: 226
61Hyaluronic acid/chondroitin sulfate3件: Chondroitin sulfate,
Hyaluronic acid,
Sulfate ion		1件: D08043 --1件: 226
62Hydrogen1件: Hydrogen---7件: 5, 6, 13, 17, 83, 97, 226
63IC Cocktail----1件: 226
64Injections on posterior bladder wall excluding the trigone----1件: 226
65Injections upper aspect of trigone of urinary bladder----1件: 226
66Interferential current----1件: 226
67Intermittent Exposure to Oxygen via Oro-Nasal Mask1件: Oxygen1件: D00003 --1件: 226
68Intravesical onabotulinumtoxinA injection1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬1件: 226
69IPD® (Japanese tradename)----1件: 226
70IPD® (suplatast tosilate)----1件: 226
71JNJ-42160443----1件: 226
72Ketorolac1件: Ketorolac2件: D00813 ,
D08104 		2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬2件: 70, 226
73Ketorolac Tromethamine2件: Ketorolac,
Tromethamine		3件: D00396 ,
D00813 ,
D08104 		2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 226
74KRP-116D----1件: 226
75Lidocaine1件: Lidocaine3件: D00358 ,
D02086 ,
D08127 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬12件: 6, 13, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256
76Lidocaine Releasing Intravesical System - LiRIS®1件: Lidocaine3件: D00358 ,
D02086 ,
D08127 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 226
77Liposome encapsulated BoNT-A----1件: 226
78Liposomes----1件: 226
79LiRIS 400 mg----1件: 226
80LiRIS low dose and LiRIS high dose----1件: 226
81LiRIS®----1件: 226
82LiRIS® 400 mg----1件: 226
83Low-dose naltrexone1件: Naltrexone2件: D02095 ,
D05113 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
84LP-08 20mg----1件: 226
85LP-08 80mg----1件: 226
86Metoprolol1件: Metoprolol3件: D00601 ,
D02358 ,
D05011 		1件: ADRB1 💬11件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 17, 57, 58, 113, 193, 226
87Metoprolol Tartrate Oral Tablet1件: Metoprolol3件: D00601 ,
D02358 ,
D05011 		1件: ADRB1 💬11件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
88Mirabegron1件: Mirabegron1件: D09535 1件: ADRB3 💬8件: Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cGMP-PKG signaling pathway 💬4件: 6, 13, 53, 226
89MMF----15件: 13, 35, 40, 46, 49, 50, 51, 60, 65, 66, 162, 222, 224, 226, 299
90MN-001----1件: 226
91MN-001 BID----1件: 226
92MR-MC-01----1件: 226
93Mycofenolate Mofetil (MMF)----1件: 226
94Mycophenolate1件: Mycophenolic acid1件: D05096 2件: IMPDH1,
IMPDH2 💬		3件: Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
95Mycophenolate mofetil2件: Mycophenolate mofetil,
Mycophenolic acid		4件: D00752 ,
D05094 ,
D05095 ,
D05096 		2件: IMPDH1,
IMPDH2 💬		3件: Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
96Naloxone1件: Naloxone2件: D01340 ,
D08249 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬2件: 6, 226
97NALOXONE HYDROCHLORIDE1件: Naloxone2件: D01340 ,
D08249 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
98Naltrexone1件: Naltrexone2件: D02095 ,
D05113 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬12件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226
99NO----12件: 6, 13, 46, 58, 62, 86, 96, 97, 222, 226, 299, 321
100Normal Saline----18件: 6, 13, 17, 22, 36, 46, 49, 60, 70, 94, 96, 210, 211, 226, 271, 276, 296, 299
101Normal saline instillation----1件: 226
102Nortriptyline1件: Nortriptyline2件: D00816 ,
D08288 		2件: SLC6A2,
SLC6A4 💬		2件: Serotonergic synapse, Synaptic vesicle cycle 💬2件: 6, 226
103OMALIZUMAB1件: Omalizumab1件: D05251 1件: FCER1A 💬4件: Asthma, Fc epsilon RI signaling pathway, Phospholipase D signaling pathway, Sphingolipid signaling pathway 💬7件: 46, 53, 65, 98, 162, 226, 299
104Onabotulinum Toxin A----1件: 226
105Onabotulinumtoxin A----2件: 51, 226
106OnabotulinumtoxinA1件: Botulinum toxin type A1件: D00783 1件: SNAP25 💬2件: Insulin secretion, Synaptic vesicle cycle 💬3件: 6, 13, 226
107Other: Hyperbaric Oxygen Therapy1件: Oxygen1件: D00003 --2件: 97, 226
108Other: inactive drug----1件: 226
109Other: normal saline----4件: 13, 222, 226, 280
110Other: Saline as a nasal spray----1件: 226
111OXN 10/5 mg PR----1件: 226
112OXN 20/10 mg PR----1件: 226
113OXN 5/2.5 mg PR----1件: 226
114Oxycodone1件: Oxycodone3件: D03783 ,
D05312 ,
D05462 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬7件: 6, 13, 46, 70, 226, 231, 298
115OXYCODONE HYDROCHLORIDE1件: Oxycodone3件: D03783 ,
D05312 ,
D05462 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬4件: 6, 70, 226, 298
116Oxycodone naloxone prolonged release tablets2件: Naloxone,
Oxycodone		5件: D01340 ,
D03783 ,
D05312 ,
D05462 ,
D08249 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
117Oxycodone/naloxone prolonged release t3件: Manganese citrate,
Naloxone,
Oxycodone		5件: D01340 ,
D03783 ,
D05312 ,
D05462 ,
D08249 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
118Oxycodone/naloxone prolonged release tablets 10/5 mg3件: Manganese citrate,
Naloxone,
Oxycodone		5件: D01340 ,
D03783 ,
D05312 ,
D05462 ,
D08249 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
119Oxycodone/naloxone prolonged release tablets 20/10 mg3件: Manganese citrate,
Naloxone,
Oxycodone		5件: D01340 ,
D03783 ,
D05312 ,
D05462 ,
D08249 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
120Oxycodone/naloxone prolonged release tablets 5/2.5 mg3件: Manganese citrate,
Naloxone,
Oxycodone		5件: D01340 ,
D03783 ,
D05312 ,
D05462 ,
D08249 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
121Oxygen1件: Oxygen1件: D00003 --20件: 6, 13, 19, 46, 49, 70, 84, 85, 86, 88, 90, 96, 97, 168, 193, 226, 271, 294, 299, 330
122Oxytocin1件: Oxytocin1件: D00089 1件: OXTR 💬4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬6件: 6, 72, 127, 193, 206, 226
123Ozone1件: Ozone---3件: 49, 51, 226
124PD 0299685----1件: 226
125PD 0299685 at 15mg BID----1件: 226
126PD 0299685 at 30mg BID----1件: 226
127PD-02996851件: PD-0299685---1件: 226
128Pelvic Floor Physical Therapy----1件: 226
129Pentosan polysulfate1件: Pentosan polysulfate1件: D05428 --3件: 19, 26, 226
130Pentosan polysulfate sodium 100 mg1件: Pentosan polysulfate1件: D05428 --1件: 226
131Peppermint1件: Peppermint1件: D05431 --1件: 226
132Peppermint oil2件: Peppermint,
Peppermint oil		2件: D05431 ,
D05432 		--1件: 226
133PF-04383119----1件: 226
134Placebo----27件: 3, 5, 6, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
135Platelet enriched plasma----1件: 226
136Platelet-Rich Plasma----1件: 226
137Prograf1件: Tacrolimus2件: D00107 ,
D08556 		5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬3件: 60, 222, 226
138Propiverine1件: Propiverine1件: D08441 9件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		43件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Regulation of actin cytoskeleton, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
139Propiverine Hydrochloride1件: Propiverine1件: D08441 9件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		43件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Regulation of actin cytoskeleton, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 226
140Release1件: Manganese citrate---12件: 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299
141RIMSO 50----1件: 226
142RN624, RI624----1件: 226
143Sandimmun----2件: 97, 226
144Sandimmun Neoral1件: Cyclosporine1件: D00184 5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬3件: 60, 97, 226
145Sham Cystoscopy Procedure----1件: 226
146SI-722----1件: 226
147Sildenafil1件: Sildenafil2件: D02229 ,
D08514 		1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
148Sulfate1件: Sulfate ion---27件: 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 79, 85, 86, 96, 111, 218, 222, 226, 265, 296, 297, 299
149Suplatast tosilate----1件: 226
150Tacrolimus1件: Tacrolimus2件: D00107 ,
D08556 		5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
151Tanezumab1件: Tanezumab1件: D09387 1件: NGF 💬9件: Apoptosis, Calcium signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Ras signaling pathway 💬2件: 226, 298
152Targinact 10 mg/5 mg prolonged-release tablets1件: Manganese citrate---2件: 6, 226
153Targinact 20mg/10 mg prolonged-release tablets1件: Manganese citrate---1件: 226
154Targinact 5mg/2.5 mg prolonged-release tablets1件: Manganese citrate---1件: 226
155Tissue examination for protein- and mRNA-expression of NO----1件: 226
156Tramadol1件: Tramadol2件: D01355 ,
D08623 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬5件: 46, 70, 78, 226, 271
157Triamcinolone1件: Triamcinolone5件: D00385 ,
D00983 ,
D00984 ,
D00985 ,
D06216 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬10件: 35, 46, 56, 70, 90, 96, 107, 162, 226, 298
158Tromethamine1件: Tromethamine1件: D00396 --1件: 226
159TTI-1612----1件: 226
160URG101----1件: 226
161Urodynamic study----1件: 226
162Water1件: Water1件: D00001 --23件: 2, 5, 6, 13, 17, 19, 22, 35, 46, 51, 53, 56, 57, 63, 65, 67, 78, 84, 96, 97, 226, 278, 299
163YM672----1件: 226
164YM672 (IPD®)----1件: 226