Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D09916 Ivacaftor [1] 299
2 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D10134 Lumacaftor [1] 299
3 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11041 Tezacaftor [1] 299
4 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11423 Deutivacaftor [1] 299
5 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11507 Elexacaftor [1] 299
6 CFTR [4] Tight junction, Gastric acid secretion, Pancreatic secretion, Vibrio cholerae infection D11724 Galicaftor [1] 299
7 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00113 Atropine [2] 2, 299
8 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00138 Scopolamine [1] 2
9 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00270 Chlorpromazine [1] 254
10 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00397 Tropicamide [3] 6, 13, 19
11 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00465 Oxybutynin [3] 6, 13, 53
12 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00481 Propantheline [1] 26
13 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00525 Pilocarpine [3] 6, 53, 299
14 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00646 Tolterodine [2] 17, 53
15 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00661 Cevimeline [1] 53
16 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00722 Oxybutynin [3] 6, 13, 53
17 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00765 Rocuronium [1] 296
18 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00787 Trihexyphenidyl [2] 5, 6
19 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00789 Chlorpromazine [1] 254
20 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01000 Bethanechol [1] 98
21 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01077 Atropine [2] 2, 299
22 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01148 Tolterodine [2] 17, 53
23 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01269 Solifenacin [3] 6, 13, 53
24 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01699 Darifenacin [2] 6, 13
25 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D02069 Atropine [2] 2, 299
26 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D02200 Pilocarpine [3] 6, 53, 299
27 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D02212 Ipratropium [2] 6, 86
28 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03011 Atropine [2] 2, 299
29 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03274 Chlorpromazine [1] 254
30 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03654 Darifenacin [2] 6, 13
31 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03814 Atropine [2] 2, 299
32 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D04034 Chlorpromazine [1] 254
33 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D05478 Pilocarpine [3] 6, 53, 299
34 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D07226 Fesoterodine [1] 6
35 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D07667 Cevimeline [1] 53
36 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08441 Propiverine [1] 226
37 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08522 Solifenacin [3] 6, 13, 53
38 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08638 Trihexyphenidyl [2] 5, 6
39 CHRM3 [8] Neuroactive ligand-receptor interaction, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D11383 Blarcamesine [1] 156
40 HRH2 [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D00295 Cimetidine [2] 2, 254
41 HRH2 [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D00318 Famotidine [7] 6, 46, 61, 86, 98, 107, 300
42 HRH2 [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D00422 Ranitidine [2] 13, 65
43 HRH2 [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D00673 Ranitidine [2] 13, 65
44 HRH2 [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D03503 Cimetidine [2] 2, 254
45 HRH2 [2] Neuroactive ligand-receptor interaction, Gastric acid secretion D08040 Histamine [1] 13
46 KCNQ1 [4] Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D00636 Amiodarone [2] 28, 127
47 KCNQ1 [4] Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D02910 Amiodarone [2] 28, 127
48 KCNQ1 [4] Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D09569 Ezogabine [2] 2, 144
49 ATP1A1 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin [1] 299
50 ATP1A1 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin [3] 8, 46, 210
51 ATP1A2 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin [1] 299
52 ATP1A2 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin [3] 8, 46, 210
53 ATP1A3 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin [1] 299
54 ATP1A3 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin [3] 8, 46, 210
55 ATP1A4 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00297 Digitoxin [1] 299
56 ATP1A4 [9] Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Mineral absorption D00298 Digoxin [3] 8, 46, 210
57 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00355 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299
58 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00455 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
59 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00724 Rabeprazole [2] 2, 51
60 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D01207 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
61 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D01984 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
62 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D02593 Pantoprazole [2] 13, 65
63 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D04056 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
64 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05259 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
65 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05261 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
66 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05353 Pantoprazole [2] 13, 65
67 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D07917 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
68 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08463 Rabeprazole [2] 2, 51
69 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08903 Dexlansoprazole [1] 98
70 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D09339 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
71 ATP4A [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D11784 Vonoprazan [2] 63, 98
72 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00355 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299
73 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00455 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
74 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D00724 Rabeprazole [2] 2, 51
75 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D01207 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
76 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D01984 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
77 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D02593 Pantoprazole [2] 13, 65
78 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D04056 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
79 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05259 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
80 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05261 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
81 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D05353 Pantoprazole [2] 13, 65
82 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D07917 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
83 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08463 Rabeprazole [2] 2, 51
84 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D08903 Dexlansoprazole [1] 98
85 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D09339 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
86 ATP4B [3] Oxidative phosphorylation, Metabolic pathways, Gastric acid secretion D11784 Vonoprazan [2] 63, 98
87 SSTR2 [3] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D00442 Octreotide [7] 67, 75, 84, 85, 89, 193, 227
88 SSTR2 [3] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D06495 Octreotide [7] 67, 75, 84, 85, 89, 193, 227
89 SSTR2 [3] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D07431 Somatostatin [2] 67, 78
90 SSTR2 [3] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D10147 Pasireotide [3] 67, 74, 75
91 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
92 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00518 Diclofenamide [1] 114
93 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
94 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D00653 Dorzolamide [1] 90
95 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
96 CA2 [5] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Gastric acid secretion, Pancreatic secretion D07871 Dorzolamide [1] 90