Target Gene/Pathway Pathway / Gene

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No.

KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[8] Proteasome, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases

Bortezomib 💬

[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
26	HTLV-1-associated myelopathy
28	Systemic amyloidosis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
51	Scleroderma
61	Autoimmune hemolytic anemia
63	Idiopathic thrombocytopenic purpura
64	Thrombotic thrombocytopenic purpura
66	IgA nephropathy
222	Primary nephrotic syndrome
228	Bronchiolitis obliterans
256	Muscle glycogenosis
283	Acquired pure red cell aplasia
288	Autoimmune acquired coagulation factor deficiency
331	Idiopathic multicentric castleman disease

2

[8] Proteasome, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases

Carfilzomib 💬

[1] 28 💬

3

[8] Proteasome, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases

[5] 13, 16, 28, 51, 61 💬