Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Huntington disease 💬

[1] CACNA1B 💬

Cilnidipine 💬

[1] 67 💬

2

Huntington disease 💬

[1] CASP9 💬

[6] 19, 60, 65, 284, 285, 326 💬

3

Huntington disease 💬

[4] GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Perampanel 💬

[3] 2 , 6 , 144 💬

4

Huntington disease 💬

[4] GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Talampanel 💬

[2] 2 , 6 💬

5

Huntington disease 💬

[4] GRIA1, GRIA2, GRIA3, GRIA4 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4

Topiramate 💬

[6] 6 , 97, 140, 144, 156, 193 💬

6

Huntington disease 💬

[6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2B 💬

Name	Full Name
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B

[9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
17	Multiple system atrophy;MSA-C;MSA-P;
18	Spinocerebellar degeneration;SCD;
203	22q11.2 deletion syndrome;
206	Fragile X syndrome;

7

Huntington disease 💬

[2] GRIN1, GRIN2B 💬

Acamprosate 💬

[2] 6 , 206 💬

8

Huntington disease 💬

[2] GRIN1, GRIN2B 💬

Amantadine 💬

[4] 6 , 8 , 13, 127 💬

9

Huntington disease 💬

[2] GRIN1, GRIN2B 💬

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

10

Huntington disease 💬

[2] GRIN1, GRIN2B 💬

Esketamine 💬

[3] 2 , 4 , 70 💬

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