Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Bile secretion 💬

[1] CA2 💬

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Collecting duct acid secretion 💬

[1] CA2 💬

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Gastric acid secretion 💬

[1] CA2 💬

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Metabolic pathways 💬

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Nitrogen metabolism 💬

[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9 💬

Name	Full Name
CA1	carbonic anhydrase 1
CA12	carbonic anhydrase 12
CA13	carbonic anhydrase 13
CA14	carbonic anhydrase 14
CA2	carbonic anhydrase 2
CA3	carbonic anhydrase 3
CA4	carbonic anhydrase 4
CA5A	carbonic anhydrase 5A
CA5B	carbonic anhydrase 5B
CA6	carbonic anhydrase 6
CA7	carbonic anhydrase 7
CA8	carbonic anhydrase 8
CA9	carbonic anhydrase 9

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Pancreatic secretion 💬

[1] CA2 💬

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Proximal tubule bicarbonate reclamation 💬

[2] CA2, CA4 💬

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;