Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
BTK [1] BTK 💬 |
Acalabrutinib Acalabrutinib 💬 |
Acalabrutinib | 046 [2] 46, 61 💬 💬 |
2 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
BTK [1] BTK 💬 |
Branebrutinib Branebrutinib 💬 |
Branebrutinib | 046 [3] 46, 49, 53 💬 💬 |
3 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
BTK [1] BTK 💬 |
Evobrutinib Evobrutinib 💬 |
Evobrutinib | 013 [3] 13, 46, 49 💬 💬 |
4 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
BTK [1] BTK 💬 |
Fenebrutinib Fenebrutinib 💬 |
Fenebrutinib | 013 [1] 13 💬 💬 |
5 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
BTK [1] BTK 💬 |
Ibrutinib Ibrutinib 💬 |
Ibrutinib | 028 [3] 28, 60, 61 💬 💬 |
6 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
BTK [1] BTK 💬 |
Orelabrutinib Orelabrutinib 💬 |
Orelabrutinib | 013 [4] 13, 49, 61, 63 💬 💬 |
7 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
BTK [1] BTK 💬 |
Remibrutinib Remibrutinib 💬 |
Remibrutinib | 013 [2] 13, 53 💬 💬 |
8 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
BTK [1] BTK 💬 |
Zanubrutinib Zanubrutinib 💬 |
Zanubrutinib | 013 [5] 13, 63, 222, 300, 331 💬 💬 |
9 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
CD19 [1] CD19 💬 |
Inebilizumab Inebilizumab 💬 |
Inebilizumab | 011 [4] 11, 13, 51, 300 💬 💬 |
10 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
CD19 [1] CD19 💬 |
Obexelimab Obexelimab 💬 |
Obexelimab | 300 [1] 300 💬 💬 |
11 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
CD22 [1] CD22 💬 |
Epratuzumab Epratuzumab 💬 |
Epratuzumab | 049 [1] 49 💬 💬 |
12 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
LILRA4 [1] LILRA4 💬 |
Daxdilimab Daxdilimab 💬 |
Daxdilimab | 049 [2] 49, 50 💬 💬 |
13 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Binimetinib Binimetinib 💬 |
Binimetinib | 034 [1] 34 💬 💬 |
14 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Cobimetinib Cobimetinib 💬 |
Cobimetinib | 280 [1] 280 💬 💬 |
15 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Mirdametinib Mirdametinib 💬 |
Mirdametinib | 034 [1] 34 💬 💬 |
16 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Selumetinib Selumetinib 💬 |
Selumetinib | 034 [1] 34 💬 💬 |
17 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
18 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
NFKB1 [1] NFKB1 💬 |
Iguratimod Iguratimod 💬 |
Iguratimod | 046 [5] 46, 51, 53, 271, 300 💬 💬 |
19 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PIK3CA [1] PIK3CA 💬 |
Alpelisib Alpelisib 💬 |
Alpelisib | 138 [1] 138 💬 💬 |
20 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬 |
Leniolisib Leniolisib 💬 |
Leniolisib | 053 [2] 53, 65 💬 💬 |
21 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PIK3CD [1] PIK3CD 💬 |
Parsaclisib Parsaclisib 💬 |
Parsaclisib | 035 [3] 35, 53, 61 💬 💬 |
22 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
23 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Pimecrolimus Pimecrolimus 💬 |
Pimecrolimus | 160 [1] 160 💬 💬 |
24 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
25 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
26 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Voclosporin Voclosporin 💬 |
Voclosporin | 049 [2] 49, 222 💬 💬 |
27 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PRKCB [1] PRKCB 💬 |
Enzastaurin Enzastaurin 💬 |
Enzastaurin | 168 [1] 168 💬 💬 |
28 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
RAF1 [1] RAF1 💬 |
Sorafenib Sorafenib 💬 |
Sorafenib | 034 [2] 34, 86 💬 💬 |
29 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
30 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
SYK [1] SYK 💬 |
Fostamatinib Fostamatinib 💬 |
Fostamatinib | 046 [4] 46, 49, 61, 66 💬 💬 |
31 | Bacterial invasion of epithelial cells 💬 5 genes, 7 drugs (DrugBank) and 13 diseases |
MET [1] MET 💬 |
Cabozantinib Cabozantinib 💬 |
Cabozantinib | 034 [1] 34 💬 💬 |
32 | Bacterial invasion of epithelial cells 💬 5 genes, 7 drugs (DrugBank) and 13 diseases |
PIK3CA [1] PIK3CA 💬 |
Alpelisib Alpelisib 💬 |
Alpelisib | 138 [1] 138 💬 💬 |
33 | Bacterial invasion of epithelial cells 💬 5 genes, 7 drugs (DrugBank) and 13 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬 |
Leniolisib Leniolisib 💬 |
Leniolisib | 053 [2] 53, 65 💬 💬 |
34 | Bacterial invasion of epithelial cells 💬 5 genes, 7 drugs (DrugBank) and 13 diseases |
PIK3CD [1] PIK3CD 💬 |
Parsaclisib Parsaclisib 💬 |
Parsaclisib | 035 [3] 35, 53, 61 💬 💬 |
35 | Bacterial invasion of epithelial cells 💬 5 genes, 7 drugs (DrugBank) and 13 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
36 | Bacterial invasion of epithelial cells 💬 5 genes, 7 drugs (DrugBank) and 13 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
37 | Bacterial invasion of epithelial cells 💬 5 genes, 7 drugs (DrugBank) and 13 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
38 | Bacterial invasion of epithelial cells 💬 5 genes, 7 drugs (DrugBank) and 13 diseases |
SRC [1] SRC 💬 |
Saracatinib Saracatinib 💬 |
Saracatinib | 006 [3] 6 , 89, 272 💬 💬 |
39 | Basal cell carcinoma 💬 1 gene, 2 drugs (DrugBank) and 1 disease |
SMO [1] SMO 💬 |
Taladegib Taladegib 💬 |
Taladegib | 085 [1] 85 💬 💬 |
40 | Basal cell carcinoma 💬 1 gene, 2 drugs (DrugBank) and 1 disease |
SMO [1] SMO 💬 |
Vismodegib Vismodegib 💬 |
Vismodegib | 085 [1] 85 💬 💬 |
41 | Base excision repair 💬 2 genes, 1 drug (DrugBank) and 2 diseases |
PARP1 [2] PARP1, PARP2 💬 |
Olaparib Olaparib 💬 |
Olaparib | 086 [2] 86, 285 💬 💬 |
42 | beta-Alanine metabolism 💬 4 genes, 3 drugs (DrugBank) and 17 diseases |
ABAT [1] ABAT 💬 |
Vigabatrin Vigabatrin 💬 |
Vigabatrin | 145 [2] 145, 158 💬 💬 |
43 | beta-Alanine metabolism 💬 4 genes, 3 drugs (DrugBank) and 17 diseases |
ABAT [3] ABAT, GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
44 | beta-Alanine metabolism 💬 4 genes, 3 drugs (DrugBank) and 17 diseases |
AOC3 [1] AOC3 💬 |
Hydralazine Hydralazine 💬 |
Hydralazine | 067 [1] 67 💬 💬 |
45 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digitoxin Digitoxin 💬 |
Digitoxin | 299 [1] 299 💬 💬 |
46 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
47 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CA2 [1] CA2 💬 |
Acetazolamide Acetazolamide 💬 |
Acetazolamide | 013 [8] 13, 86, 90, 115, 154, 155, 225, 230 💬 💬 |
48 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CA2 [1] CA2 💬 |
Dichlorphenamide Dichlorphenamide 💬 |
Diclofenamide | 114 [1] 114 💬 💬 |
49 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CA2 [1] CA2 💬 |
Dorzolamide Dorzolamide 💬 |
Dorzolamide | 090 [1] 90 💬 💬 |
50 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CA2 [1] CA2 💬 |
Topiramate Topiramate 💬 |
Topiramate | 006 [6] 6 , 97, 140, 144, 156, 193 💬 💬 |
51 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CFTR [1] CFTR 💬 |
Deutivacaftor Deutivacaftor 💬 |
Deutivacaftor | 299 [1] 299 💬 💬 |
52 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CFTR [1] CFTR 💬 |
Elexacaftor Elexacaftor 💬 |
Elexacaftor | 299 [1] 299 💬 💬 |
53 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CFTR [1] CFTR 💬 |
Galicaftor Galicaftor 💬 |
Galicaftor | 299 [1] 299 💬 💬 |
54 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CFTR [1] CFTR 💬 |
Ivacaftor Ivacaftor 💬 |
Ivacaftor | 299 [1] 299 💬 💬 |
55 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CFTR [1] CFTR 💬 |
Lumacaftor Lumacaftor 💬 |
Lumacaftor | 299 [1] 299 💬 💬 |
56 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
CFTR [1] CFTR 💬 |
Tezacaftor Tezacaftor 💬 |
Tezacaftor | 299 [1] 299 💬 💬 |
57 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
HMGCR [1] HMGCR 💬 |
Atorvastatin Atorvastatin 💬 |
Atorvastatin | 013 [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬 |
58 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
HMGCR [1] HMGCR 💬 |
Fluvastatin Fluvastatin 💬 |
Fluvastatin | 079 [3] 79, 218, 222 💬 💬 |
59 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
HMGCR [1] HMGCR 💬 |
Lovastatin Lovastatin 💬 |
Lovastatin | 006 [11] 6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 💬 |
60 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
HMGCR [1] HMGCR 💬 |
Pravastatin Pravastatin 💬 |
Pravastatin | 013 [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬 💬 |
61 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
HMGCR [1] HMGCR 💬 |
Rosuvastatin Rosuvastatin 💬 |
Rosuvastatin | 006 [11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬 💬 |
62 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
HMGCR [1] HMGCR 💬 |
Simvastatin Simvastatin 💬 |
Simvastatin | 006 [21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 💬 |
63 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
NR1H4 [1] NR1H4 💬 |
Chenodiol Chenodiol 💬 |
Chenodeoxycholic acid | 020 [4] 20, 96, 234, 263 💬 💬 |
64 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
NR1H4 [1] NR1H4 💬 |
Cholic acid Cholic acid 💬 |
Cholic Acid | 020 [4] 20, 234, 265, 310 💬 💬 |
65 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
NR1H4 [1] NR1H4 💬 |
Obeticholic acid Obeticholic acid 💬 |
Obeticholic acid | 093 [3] 93, 265, 296 💬 💬 |
66 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
NR1H4 [1] NR1H4 💬 |
Tropifexor Tropifexor 💬 |
Tropifexor | 093 [1] 93 💬 💬 |
67 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
NR1H4 [1] NR1H4 💬 |
Ursodiol Ursodiol 💬 |
Ursodeoxycholic acid | 006 [14] 6 , 8 , 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬 💬 |
68 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
RXRA [1] RXRA 💬 |
Acitretin Acitretin 💬 |
Acitretin | 037 [1] 37 💬 💬 |
69 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
RXRA [1] RXRA 💬 |
Alitretinoin Alitretinoin 💬 |
Alitretinoin | 049 [1] 49 💬 💬 |
70 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
RXRA [1] RXRA 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
71 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
SLC10A1 [2] SLC10A1, SLC10A2 💬 |
Maralixibat Maralixibat 💬 |
Maralixibat | 296 [3] 296, 297, 338 💬 💬 |
72 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
SLC10A2 [1] SLC10A2 💬 |
Elobixibat Elobixibat 💬 |
Elobixibat | 006 [1] 6 💬 💬 |
73 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
SLC10A2 [1] SLC10A2 💬 |
Odevixibat Odevixibat 💬 |
Odevixibat | 296 [3] 296, 297, 338 💬 💬 |
74 | Biosynthesis of amino acids 💬 2 genes, 2 drugs (DrugBank) and 4 diseases |
CPS1 [1] CPS1 💬 |
Carglumic acid Carglumic acid 💬 |
Carglumic acid | 245 [3] 245, 246, 251 💬 💬 |
75 | Biosynthesis of amino acids 💬 2 genes, 2 drugs (DrugBank) and 4 diseases |
PAH [1] PAH 💬 |
Pegvaliase Pegvaliase 💬 |
Pegvaliase | 240 [1] 240 💬 💬 |
76 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
ALAS1 [1] ALAS1 💬 |
Givosiran Givosiran 💬 |
Givosiran | 254 [1] 254 💬 💬 |
77 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
ALAS1 [2] ALAS1, ALAS2 💬 |
Hemin Hemin 💬 |
Hemin | 254 [1] 254 💬 💬 |
78 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
ALPL [1] ALPL 💬 |
Asfotase alfa Asfotase alfa 💬 |
Asfotase alfa | 172 [1] 172 💬 💬 |
79 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
DHFR [2] DHFR, DHFR2 💬 |
Methotrexate Methotrexate 💬 |
Methotrexate | 011 [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 💬 |
80 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
DHODH [1] DHODH 💬 |
Leflunomide Leflunomide 💬 |
Leflunomide | 011 [12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬 💬 |
81 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
DHODH [1] DHODH 💬 |
Teriflunomide Teriflunomide 💬 |
Teriflunomide | 013 [3] 13, 25, 26 💬 💬 |
82 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
GUSB [1] GUSB 💬 |
Vestronidase alfa Vestronidase alfa 💬 |
Vestronidase alfa | 019 [1] 19 💬 💬 |
83 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
HPD [1] HPD 💬 |
Nitisinone Nitisinone 💬 |
Nitisinone | 006 [3] 6 , 164, 241 💬 💬 |
84 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
Warfarin Warfarin 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬 💬 |
85 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 51 diseases |
VKORC1 [1] VKORC1 💬 |
Phenindione Phenindione 💬 |
Phenindione | 065 [1] 65 💬 💬 |
86 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
BRAF [1] BRAF 💬 |
Dabrafenib Dabrafenib 💬 |
Dabrafenib | 034 [1] 34 💬 💬 |
87 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
BRAF [2] BRAF, RAF1 💬 |
Sorafenib Sorafenib 💬 |
Sorafenib | 034 [2] 34, 86 💬 💬 |
88 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
CDK4 [1] CDK4 💬 |
Abemaciclib Abemaciclib 💬 |
Abemaciclib | 034 [1] 34 💬 💬 |
89 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
EGFR [1] EGFR 💬 |
Cetuximab Cetuximab 💬 |
Cetuximab | 051 [2] 51, 86 💬 💬 |
90 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
EGFR [1] EGFR 💬 |
Erlotinib Erlotinib 💬 |
Erlotinib | 094 [1] 94 💬 💬 |
91 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
92 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
EGFR [1] EGFR 💬 |
Icotinib Icotinib 💬 |
Icotinib | 034 [1] 34 💬 💬 |
93 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
94 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Neratinib Neratinib 💬 |
Neratinib | 034 [1] 34 💬 💬 |
95 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Tesevatinib Tesevatinib 💬 |
Tesevatinib | 067 [1] 67 💬 💬 |
96 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
FGFR3 [1] FGFR3 💬 |
Infigratinib Infigratinib 💬 |
Infigratinib | 276 [1] 276 💬 💬 |
97 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
FGFR3 [1] FGFR3 💬 |
Nintedanib Nintedanib 💬 |
Nintedanib | 051 [5] 51, 85, 89, 227, 228 💬 💬 |
98 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Binimetinib Binimetinib 💬 |
Binimetinib | 034 [1] 34 💬 💬 |
99 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Cobimetinib Cobimetinib 💬 |
Cobimetinib | 280 [1] 280 💬 💬 |
100 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Mirdametinib Mirdametinib 💬 |
Mirdametinib | 034 [1] 34 💬 💬 |
101 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Selumetinib Selumetinib 💬 |
Selumetinib | 034 [1] 34 💬 💬 |
102 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
103 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
104 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
105 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
106 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
SRC [1] SRC 💬 |
Saracatinib Saracatinib 💬 |
Saracatinib | 006 [3] 6 , 89, 272 💬 💬 |
107 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
VEGFA [1] VEGFA 💬 |
Aflibercept Aflibercept 💬 |
Aflibercept | 090 [2] 90, 166 💬 💬 |
108 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
VEGFA [1] VEGFA 💬 |
Bevacizumab Bevacizumab 💬 |
Bevacizumab | 013 [6] 13, 34, 85, 87, 227, 280 💬 💬 |
109 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
VEGFA [1] VEGFA 💬 |
Ranibizumab Ranibizumab 💬 |
Ranibizumab | 034 [4] 34, 166, 227, 301 💬 💬 |
110 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
BRAF [1] BRAF 💬 |
Dabrafenib Dabrafenib 💬 |
Dabrafenib | 034 [1] 34 💬 💬 |
111 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
BRAF [4] BRAF, FLT4, KIT, RAF1 💬 |
Sorafenib Sorafenib 💬 |
Sorafenib | 034 [2] 34, 86 💬 💬 |
112 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
CDK4 [2] CDK4, CDK6 💬 |
Abemaciclib Abemaciclib 💬 |
Abemaciclib | 034 [1] 34 💬 💬 |
113 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
EGFR [1] EGFR 💬 |
Cetuximab Cetuximab 💬 |
Cetuximab | 051 [2] 51, 86 💬 💬 |
114 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
EGFR [1] EGFR 💬 |
Erlotinib Erlotinib 💬 |
Erlotinib | 094 [1] 94 💬 💬 |
115 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
116 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
EGFR [1] EGFR 💬 |
Icotinib Icotinib 💬 |
Icotinib | 034 [1] 34 💬 💬 |
117 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
118 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Neratinib Neratinib 💬 |
Neratinib | 034 [1] 34 💬 💬 |
119 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
EGFR [3] EGFR, ERBB2, FLT4 💬 |
Tesevatinib Tesevatinib 💬 |
Tesevatinib | 067 [1] 67 💬 💬 |
120 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [1] ESR1 💬 |
Ethinyl estradiol Ethinyl estradiol 💬 |
Ethinylestradiol | 013 [4] 13, 46, 49, 299 💬 💬 |
121 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Clomifene Clomifene 💬 |
Clomifene | 074 [1] 74 💬 💬 |
122 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Estetrol Estetrol 💬 |
Estetrol | 053 [1] 53 💬 💬 |
123 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Estetrol Estetrol 💬 |
Estetrol | 053 [1] 53 💬 💬 |
124 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Estradiol Estradiol 💬 |
Estradiol | 013 [7] 13, 46, 49, 65, 76, 226, 299 💬 💬 |
125 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Estradiol valerate Estradiol valerate 💬 |
Estradiol valerate | 065 [1] 65 💬 💬 |
126 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Estriol Estriol 💬 |
Estriol | 013 [2] 13, 227 💬 💬 |
127 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Estriol tripropionate Estriol tripropionate 💬 |
Estriol | 013 [2] 13, 227 💬 💬 |
128 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Fulvestrant Fulvestrant 💬 |
Fulvestrant | 049 [2] 49, 86 💬 💬 |
129 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Mestranol Mestranol 💬 |
Mestranol | 046 [2] 46, 49 💬 💬 |
130 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
131 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Raloxifene Raloxifene 💬 |
Raloxifene | 046 [1] 46 💬 💬 |
132 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
133 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, PGR 💬 |
Danazol Danazol 💬 |
Danazol | 060 [5] 60, 63, 64, 65, 285 💬 💬 |
134 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, PGR 💬 |
Desogestrel Desogestrel 💬 |
Desogestrel | 230 [1] 230 💬 💬 |
135 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
FGF23 [1] FGF23 💬 |
Burosumab Burosumab 💬 |
Burosumab | 238 [1] 238 💬 💬 |
136 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
FGFR1 [1] FGFR1 💬 |
Infigratinib Infigratinib 💬 |
Infigratinib | 276 [1] 276 💬 💬 |
137 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
FGFR1 [2] FGFR1, FLT4 💬 |
Nintedanib Nintedanib 💬 |
Nintedanib | 051 [5] 51, 85, 89, 227, 228 💬 💬 |
138 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
FLT4 [1] FLT4 💬 |
Axitinib Axitinib 💬 |
Axitinib | 034 [1] 34 💬 💬 |
139 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
FLT4 [1] FLT4 💬 |
Cediranib Cediranib 💬 |
Cediranib | 034 [1] 34 💬 💬 |
140 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
FLT4 [2] FLT4, KIT 💬 |
Sunitinib Sunitinib 💬 |
Sunitinib | 028 [2] 28, 34 💬 💬 |
141 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
IGF1R [1] IGF1R 💬 |
Linsitinib Linsitinib 💬 |
Linsitinib | 232 [1] 232 💬 💬 |
142 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
IGF1R [1] IGF1R 💬 |
Mecasermin Mecasermin 💬 |
Mecasermin | 065 [6] 65, 78, 96, 168, 265, 299 💬 💬 |
143 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
IGF1R [1] IGF1R 💬 |
Teprotumumab Teprotumumab 💬 |
Teprotumumab | 051 [1] 51 💬 💬 |
144 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
KIT [1] KIT 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
145 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
KIT [1] KIT 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
146 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
KIT [1] KIT 💬 |
Imatinib Imatinib 💬 |
Imatinib | 013 [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 💬 |
147 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
148 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
KIT [1] KIT 💬 |
Nilotinib Nilotinib 💬 |
Nilotinib | 006 [5] 6 , 8 , 34, 51, 86 💬 💬 |
149 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
KIT [1] KIT 💬 |
Pexidartinib Pexidartinib 💬 |
Pexidartinib | 034 [1] 34 💬 💬 |
150 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Binimetinib Binimetinib 💬 |
Binimetinib | 034 [1] 34 💬 💬 |
151 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Cobimetinib Cobimetinib 💬 |
Cobimetinib | 280 [1] 280 💬 💬 |
152 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Mirdametinib Mirdametinib 💬 |
Mirdametinib | 034 [1] 34 💬 💬 |
153 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Selumetinib Selumetinib 💬 |
Selumetinib | 034 [1] 34 💬 💬 |
154 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
155 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MTOR [1] MTOR 💬 |
Everolimus Everolimus 💬 |
Everolimus | 034 [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬 |
156 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
157 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MTOR [1] MTOR 💬 |
Temsirolimus Temsirolimus 💬 |
Temsirolimus | 013 [1] 13 💬 💬 |
158 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Dydrogesterone Dydrogesterone 💬 |
Dydrogesterone | 013 [1] 13 💬 💬 |
159 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Levonorgestrel Levonorgestrel 💬 |
Levonorgestrel | 013 [1] 13 💬 💬 |
160 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Medroxyprogesterone acetate Medroxyprogesterone acetate 💬 |
Medroxyprogesterone acetate | 013 [8] 13, 35, 46, 49, 50, 51, 60, 107 💬 💬 |
161 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Megestrol acetate Megestrol acetate 💬 |
Megestrol acetate | 076 [1] 76 💬 💬 |
162 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Mifepristone Mifepristone 💬 |
Mifepristone | 075 [1] 75 💬 💬 |
163 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Nomegestrol Nomegestrol 💬 |
Nomegestrol | 013 [1] 13 💬 💬 |
164 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Nomegestrol acetate Nomegestrol acetate 💬 |
Nomegestrol acetate | 013 [1] 13 💬 💬 |
165 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Norethindrone Norethindrone 💬 |
Norethisterone | 013 [4] 13, 46, 49, 299 💬 💬 |
166 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Norgestimate Norgestimate 💬 |
Norgestimate | 299 [1] 299 💬 💬 |
167 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Progesterone Progesterone 💬 |
Progesterone | 076 [2] 76, 299 💬 💬 |
168 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Ulipristal Ulipristal 💬 |
Ulipristal | 010 [1] 10 💬 💬 |
169 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PIK3CA [1] PIK3CA 💬 |
Alpelisib Alpelisib 💬 |
Alpelisib | 138 [1] 138 💬 💬 |
170 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬 |
Leniolisib Leniolisib 💬 |
Leniolisib | 053 [2] 53, 65 💬 💬 |
171 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PIK3CD [1] PIK3CD 💬 |
Parsaclisib Parsaclisib 💬 |
Parsaclisib | 035 [3] 35, 53, 61 💬 💬 |
172 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
TNFSF11 [1] TNFSF11 💬 |
Denosumab Denosumab 💬 |
Denosumab | 046 [8] 46, 50, 70, 93, 95, 96, 274, 299 💬 💬 |
173 | Butanoate metabolism 💬 4 genes, 2 drugs (DrugBank) and 16 diseases |
ABAT [1] ABAT 💬 |
Vigabatrin Vigabatrin 💬 |
Vigabatrin | 145 [2] 145, 158 💬 💬 |
174 | Butanoate metabolism 💬 4 genes, 2 drugs (DrugBank) and 16 diseases |
ABAT [4] ABAT, ALDH5A1, GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |