Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Valine, leucine and isoleucine degradation 💬

[1] ABAT 💬

Valproic acid 💬

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

2

Valine, leucine and isoleucine degradation 💬

[1] ABAT 💬

Vigabatrin 💬

[2] 145, 158 💬

3

Vascular smooth muscle contraction 💬

[1] ADORA2A 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

4

Vascular smooth muscle contraction 💬

[1] ADORA2A 💬

Caffeine hydrate 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

5

Vascular smooth muscle contraction 💬

[1] ADORA2A 💬

Istradefylline 💬

[1] 6 💬

6

Vascular smooth muscle contraction 💬

[1] ADORA2A 💬

Preladenant 💬

[1] 6 💬

7

Vascular smooth muscle contraction 💬

[1] ADORA2A 💬

Regadenoson 💬

[1] 58 💬

8

Vascular smooth muscle contraction 💬

[1] ADORA2A 💬

Regadenoson 💬

[1] 58 💬

9

Vascular smooth muscle contraction 💬

[1] ADORA2A 💬

Tozadenant 💬

[1] 6 💬

10

Vascular smooth muscle contraction 💬

[2] ADORA2A, ADORA2B 💬

[3] 13, 58, 65 💬

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