Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Acute myeloid leukemia 💬

[1] RARA 💬

Isotretinoin 💬

[4] 36, 39, 159, 160 💬

2

Autoimmune thyroid disease 💬

[1] CTLA4 💬

Ipilimumab 💬

[1] 159 💬

3

Cell adhesion molecules 💬

[1] CTLA4 💬

Ipilimumab 💬

[1] 159 💬

4

Cell adhesion molecules 💬

[1] PDCD1 💬

[12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
159	Xeroderma pigmentosum;XP;

5

Estrogen signaling pathway 💬

[1] RARA 💬

Isotretinoin 💬

[4] 36, 39, 159, 160 💬

6

Gastric cancer 💬

[1] RARB 💬

Isotretinoin 💬

[4] 36, 39, 159, 160 💬

7

Melanogenesis 💬

[1] MC1R 💬

Afamelanotide 💬

[3] 159, 161, 254 💬

8

Neuroactive ligand-receptor interaction 💬

[1] MC1R 💬

Afamelanotide 💬

[3] 159, 161, 254 💬

9

Non-small cell lung cancer 💬

[1] RARB 💬

Isotretinoin 💬

[4] 36, 39, 159, 160 💬

10

Pathways in cancer 💬

[2] RARA, RARB 💬

Isotretinoin 💬

[4] 36, 39, 159, 160 💬

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