Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Alcoholism 💬

[1] SLC6A3 💬

[5] 8 , 18, 21, 96, 171 💬

2

Alzheimer disease 💬

[1] PTGS2 💬

[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
89	Lymphangioleiomyomatosis;LAM;
107	Juvenile idiopathic arthritis;JIA;
161	Familial benign chronic pemphigus;Benign familial pemphigus;Hailey-Hailey disease;
171	Wilson disease;WD;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

3

Amphetamine addiction 💬

[1] SLC6A3 💬

[5] 8 , 18, 21, 96, 171 💬

4

Arachidonic acid metabolism 💬

[1] PTGS2 💬

[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
89	Lymphangioleiomyomatosis;LAM;
107	Juvenile idiopathic arthritis;JIA;
161	Familial benign chronic pemphigus;Benign familial pemphigus;Hailey-Hailey disease;
171	Wilson disease;WD;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

5

C-type lectin receptor signaling pathway 💬

[1] PTGS2 💬

[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
89	Lymphangioleiomyomatosis;LAM;
107	Juvenile idiopathic arthritis;JIA;
161	Familial benign chronic pemphigus;Benign familial pemphigus;Hailey-Hailey disease;
171	Wilson disease;WD;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

6

cGMP-PKG signaling pathway 💬

[3] ADRA2A, ADRA2B, ADRA2C 💬

Dexmedetomidine 💬

Dexmedetomidine

[14] 2 , 4 , 6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
4	Primary lateral sclerosis;PLS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
171	Wilson disease;WD;
212	Tricuspid atresia;TA;
215	Tetralogy of Fallot;Fallot tetralogy;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

7

Chemical carcinogenesis - DNA adducts 💬

[1] PTGS2 💬

[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
89	Lymphangioleiomyomatosis;LAM;
107	Juvenile idiopathic arthritis;JIA;
161	Familial benign chronic pemphigus;Benign familial pemphigus;Hailey-Hailey disease;
171	Wilson disease;WD;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

8

Cocaine addiction 💬

[1] SLC6A3 💬

[5] 8 , 18, 21, 96, 171 💬

9

Dopaminergic synapse 💬

[1] SLC6A3 💬

[5] 8 , 18, 21, 96, 171 💬

10

Human cytomegalovirus infection 💬

[1] PTGS2 💬

[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
89	Lymphangioleiomyomatosis;LAM;
107	Juvenile idiopathic arthritis;JIA;
161	Familial benign chronic pemphigus;Benign familial pemphigus;Hailey-Hailey disease;
171	Wilson disease;WD;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

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