Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

ABC transporters 💬

[1] ABCC8 💬

Repaglinide 💬

Repaglinide

[4] 6 , 21, 46, 299 💬

Alcoholism 💬

[1] ADORA2A 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Alcoholism 💬

[1] ADORA2A 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Alcoholism 💬

[1] DRD2 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

Alcoholism 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Alcoholism 💬

[1] SLC6A3 💬

Bupropion 💬

Bupropion

[5] 8 , 18, 21, 96, 171 💬

Aldosterone synthesis and secretion 💬

[1] PDE2A 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Aldosterone synthesis and secretion 💬

[1] PDE2A 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Alzheimer disease 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Alzheimer disease 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Amphetamine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Amphetamine addiction 💬

[1] SLC6A3 💬

Bupropion 💬

Bupropion

[5] 8 , 18, 21, 96, 171 💬

Amyotrophic lateral sclerosis 💬

[6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D
SIGMAR1	sigma non-opioid intracellular receptor 1

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Apelin signaling pathway 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Apelin signaling pathway 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Arachidonic acid metabolism 💬

[2] PTGS1, PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

C-type lectin receptor signaling pathway 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Calcium signaling pathway 💬

[2] ADORA2A, PDE1B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Calcium signaling pathway 💬

[2] ADORA2A, PDE1B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Calcium signaling pathway 💬

[4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Calcium signaling pathway 💬

[1] HTR2A 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

cAMP signaling pathway 💬

[8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Name	Full Name
ADORA1	adenosine A1 receptor
ADORA2A	adenosine A2a receptor
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

cAMP signaling pathway 💬

[8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Name	Full Name
ADORA1	adenosine A1 receptor
ADORA2A	adenosine A2a receptor
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

cAMP signaling pathway 💬

[2] DRD2, HTR1A 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

cAMP signaling pathway 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

cGMP-PKG signaling pathway 💬

[5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

cGMP-PKG signaling pathway 💬

[5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

cGMP-PKG signaling pathway 💬

[3] ADRA2A, ADRA2B, ADRA2C 💬

Dexmedetomidine 💬

Dexmedetomidine

[14] 2 , 4 , 6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
4	Primary lateral sclerosis;PLS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
171	Wilson disease;WD;
212	Tricuspid atresia;TA;
215	Tetralogy of Fallot;Fallot tetralogy;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

Chemical carcinogenesis - DNA adducts 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Circadian entrainment 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Cocaine addiction 💬

[1] DRD2 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

Cocaine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Cocaine addiction 💬

[1] SLC6A3 💬

Bupropion 💬

Bupropion

[5] 8 , 18, 21, 96, 171 💬

Collecting duct acid secretion 💬

[2] ATP4A, ATP4B 💬

Omeprazole 💬

Omeprazole

[14] 6 , 8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
282	Congenital dyserythropoietic anemia;CDA;
294	Congenital diaphragmatic hernia;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Dopaminergic synapse 💬

[1] DRD2 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

Dopaminergic synapse 💬

[2] GRIN2A, GRIN2B 💬

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Dopaminergic synapse 💬

[1] SLC6A3 💬

Bupropion 💬

Bupropion

[5] 8 , 18, 21, 96, 171 💬

GABAergic synapse 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Midazolam 💬

Midazolam

[12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

GABAergic synapse 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

Propofol

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

Gap junction 💬

[2] DRD2, HTR2A 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

Gastric acid secretion 💬

[2] ATP4A, ATP4B 💬

Omeprazole 💬

Omeprazole

[14] 6 , 8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
282	Congenital dyserythropoietic anemia;CDA;
294	Congenital diaphragmatic hernia;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Glucagon signaling pathway 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Glucagon signaling pathway 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Glutamatergic synapse 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

GnRH secretion 💬

[1] KCNJ11 💬

Repaglinide 💬

Repaglinide

[4] 6 , 21, 46, 299 💬

Human cytomegalovirus infection 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Human papillomavirus infection 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Huntington disease 💬

[2] GRIN1, GRIN2B 💬

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

IL-17 signaling pathway 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Inflammatory mediator regulation of TRP channels 💬

[1] HTR2A 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

Insulin secretion 💬

[2] ABCC8, KCNJ11 💬

Repaglinide 💬

Repaglinide

[4] 6 , 21, 46, 299 💬

Insulin signaling pathway 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Insulin signaling pathway 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Kaposi sarcoma-associated herpesvirus infection 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Leishmaniasis 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Long-term potentiation 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Metabolic pathways 💬

[2] ATP4A, ATP4B 💬

Omeprazole 💬

Omeprazole

[14] 6 , 8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
282	Congenital dyserythropoietic anemia;CDA;
294	Congenital diaphragmatic hernia;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Metabolic pathways 💬

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Metabolic pathways 💬

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Metabolic pathways 💬

[2] PTGS1, PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

MicroRNAs in cancer 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Morphine addiction 💬

[9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Name	Full Name
ADORA1	adenosine A1 receptor
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Morphine addiction 💬

[9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Name	Full Name
ADORA1	adenosine A1 receptor
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Morphine addiction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Midazolam 💬

Midazolam

[12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Morphine addiction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

Propofol

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

Neuroactive ligand-receptor interaction 💬

[2] ADORA1, ADORA2A 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Neuroactive ligand-receptor interaction 💬

[2] ADORA1, ADORA2A 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Neuroactive ligand-receptor interaction 💬

[3] ADRA2A, ADRA2B, ADRA2C 💬

Dexmedetomidine 💬

Dexmedetomidine

[14] 2 , 4 , 6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
4	Primary lateral sclerosis;PLS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
171	Wilson disease;WD;
212	Tricuspid atresia;TA;
215	Tetralogy of Fallot;Fallot tetralogy;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

Neuroactive ligand-receptor interaction 💬

[3] DRD2, HTR1A, HTR2A 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

Neuroactive ligand-receptor interaction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Midazolam 💬

Midazolam

[12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Neuroactive ligand-receptor interaction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

Propofol

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

Neuroactive ligand-receptor interaction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

NF-kappa B signaling pathway 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Nicotine addiction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Midazolam 💬

Midazolam

[12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Nicotine addiction 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

Propofol

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

Nicotine addiction 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Olfactory transduction 💬

[2] PDE1B, PDE2A 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Olfactory transduction 💬

[2] PDE1B, PDE2A 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Ovarian steroidogenesis 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Oxidative phosphorylation 💬

[2] ATP4A, ATP4B 💬

Omeprazole 💬

Omeprazole

[14] 6 , 8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
282	Congenital dyserythropoietic anemia;CDA;
294	Congenital diaphragmatic hernia;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Oxytocin signaling pathway 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Parathyroid hormone synthesis, secretion and action 💬

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Parathyroid hormone synthesis, secretion and action 💬

[4] PDE4A, PDE4B, PDE4C, PDE4D 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Parkinson disease 💬

[1] ADORA2A 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Parkinson disease 💬

[1] ADORA2A 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Parkinson disease 💬

[1] DRD2 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

Parkinson disease 💬

[1] SLC6A3 💬

Bupropion 💬

Bupropion

[5] 8 , 18, 21, 96, 171 💬

Pathways in cancer 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Pathways of neurodegeneration - multiple diseases 💬

[6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D
SIGMAR1	sigma non-opioid intracellular receptor 1

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Pathways of neurodegeneration - multiple diseases 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Pathways of neurodegeneration - multiple diseases 💬

[1] SLC6A3 💬

Bupropion 💬

Bupropion

[5] 8 , 18, 21, 96, 171 💬

Platelet activation 💬

[1] PTGS1 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Prion disease 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Progesterone-mediated oocyte maturation 💬

[1] PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Purine metabolism 💬

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Purine metabolism 💬

[9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬

Name	Full Name
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Rap1 signaling pathway 💬

[1] ADORA2A 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Rap1 signaling pathway 💬

[1] ADORA2A 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

100

Rap1 signaling pathway 💬

[1] DRD2 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

101

Rap1 signaling pathway 💬

[3] GRIN1, GRIN2A, GRIN2B 💬

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

102

Ras signaling pathway 💬

[3] GRIN1, GRIN2A, GRIN2B 💬

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

103

Regulation of lipolysis in adipocytes 💬

[2] ADORA1, PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

104

Regulation of lipolysis in adipocytes 💬

[2] ADORA1, PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

105

Regulation of lipolysis in adipocytes 💬

[2] PTGS1, PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

106

Renin secretion 💬

[4] ADORA1, PDE1B, PDE3A, PDE3B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

107

Renin secretion 💬

[4] ADORA1, PDE1B, PDE3A, PDE3B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

108

Retrograde endocannabinoid signaling 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Midazolam 💬

Midazolam

[12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

109

Retrograde endocannabinoid signaling 💬

[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1
GABRB2	gamma-aminobutyric acid type A receptor subunit beta2
GABRB3	gamma-aminobutyric acid type A receptor subunit beta3
GABRD	gamma-aminobutyric acid type A receptor subunit delta
GABRE	gamma-aminobutyric acid type A receptor subunit epsilon
GABRG1	gamma-aminobutyric acid type A receptor subunit gamma1
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2
GABRG3	gamma-aminobutyric acid type A receptor subunit gamma3
GABRP	gamma-aminobutyric acid type A receptor subunit pi
GABRQ	gamma-aminobutyric acid type A receptor subunit theta

Propofol 💬

Propofol

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

110

Retrograde endocannabinoid signaling 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

111

Serotonergic synapse 💬

[3] GABRB1, GABRB2, GABRB3 💬

Midazolam 💬

Midazolam

[12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

112

Serotonergic synapse 💬

[3] GABRB1, GABRB2, GABRB3 💬

Propofol 💬

Propofol

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

113

Serotonergic synapse 💬

[2] HTR1A, HTR2A 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

114

Serotonergic synapse 💬

[2] PTGS1, PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

115

Small cell lung cancer 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

116

Sphingolipid signaling pathway 💬

[1] ADORA1 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

117

Sphingolipid signaling pathway 💬

[1] ADORA1 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

118

Spinocerebellar ataxia 💬

[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

119

Synaptic vesicle cycle 💬

[2] SLC6A2, SLC6A3 💬

Bupropion 💬

Bupropion

[5] 8 , 18, 21, 96, 171 💬

120

Systemic lupus erythematosus 💬

[2] GRIN2A, GRIN2B 💬

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

121

Taste transduction 💬

[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6

Midazolam 💬

Midazolam

[12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
272	Fibrodysplasia ossificans progressiva;FOP;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

122

Taste transduction 💬

[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬

Name	Full Name
GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1
GABRA2	gamma-aminobutyric acid type A receptor subunit alpha2
GABRA3	gamma-aminobutyric acid type A receptor subunit alpha3
GABRA4	gamma-aminobutyric acid type A receptor subunit alpha4
GABRA5	gamma-aminobutyric acid type A receptor subunit alpha5
GABRA6	gamma-aminobutyric acid type A receptor subunit alpha6

Propofol 💬

Propofol

[9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
75	Cushing disease;Cushing;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
296	Biliary atresia;

123

Taste transduction 💬

[1] HTR1A 💬

Cariprazine 💬

Cariprazine

[1] 21 💬

124

Taste transduction 💬

[1] PDE1B 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

125

Taste transduction 💬

[1] PDE1B 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

126

TNF signaling pathway 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

127

Type II diabetes mellitus 💬

[2] ABCC8, KCNJ11 💬

Repaglinide 💬

Repaglinide

[4] 6 , 21, 46, 299 💬

128

Vascular smooth muscle contraction 💬

[1] ADORA2A 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

129

Vascular smooth muscle contraction 💬

[1] ADORA2A 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

130

VEGF signaling pathway 💬

[1] PTGS2 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬