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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Calcium signaling pathway 💬

[1] EDNRA 💬

Ambrisentan 💬

Ambrisentan

[7] 51, 84, 85, 86, 88, 210, 211 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;

Calcium signaling pathway 💬

[2] EDNRA, EDNRB 💬

Bosentan 💬

Bosentan

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
47	Buerger disease;Thromboangiitis obliterans;
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;

Calcium signaling pathway 💬

[2] EDNRA, EDNRB 💬

Bosentan 💬

Bosentan

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
47	Buerger disease;Thromboangiitis obliterans;
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;

cAMP signaling pathway 💬

[1] EDNRA 💬

Ambrisentan 💬

Ambrisentan

[7] 51, 84, 85, 86, 88, 210, 211 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;

cAMP signaling pathway 💬

[1] EDNRA 💬

Bosentan 💬

Bosentan

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
47	Buerger disease;Thromboangiitis obliterans;
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;

cAMP signaling pathway 💬

[1] EDNRA 💬

Bosentan 💬

Bosentan

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
47	Buerger disease;Thromboangiitis obliterans;
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;

cGMP-PKG signaling pathway 💬

[1] EDNRA 💬

Ambrisentan 💬

Ambrisentan

[7] 51, 84, 85, 86, 88, 210, 211 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;

cGMP-PKG signaling pathway 💬

[2] EDNRA, EDNRB 💬

Bosentan 💬

Bosentan

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
47	Buerger disease;Thromboangiitis obliterans;
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;

cGMP-PKG signaling pathway 💬

[2] EDNRA, EDNRB 💬

Bosentan 💬

Bosentan

[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
47	Buerger disease;Thromboangiitis obliterans;
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;

cGMP-PKG signaling pathway 💬

[1] PDE5A 💬

Sildenafil 💬

Sildenafil

[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
211	Hypoplastic left heart syndrome;HLHS;
212	Tricuspid atresia;TA;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
278	Huge lymphatic malformation with cervicofacial lesion;Huge lymphatic malformation;Lymphatic malformation;
294	Congenital diaphragmatic hernia;
299	Cystic fibrosis;
301	Macular dystrophy;

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