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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Chemical carcinogenesis - receptor activation 💬

[1] VDR 💬

Alfacalcidol 💬

Alfacalcidol

[8] 41, 46, 49, 50, 96, 107, 235, 238 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
96	Crohn disease;Terminal ileitis;
107	Juvenile idiopathic arthritis;JIA;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
238	Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;

Chemical carcinogenesis - receptor activation 💬

[1] VDR 💬

Calcitriol 💬

Calcitriol

[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬

Disease ID	Name
18	Spinocerebellar degeneration;SCD;
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
158	Tuberous sclerosis;Tuberous sclerosis complex;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
326	Osteopetrosis;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] PTH1R 💬

Parathyroid hormone 💬

Parathyroid hormone

[4] 65, 70, 235, 326 💬

Endocrine and other factor-regulated calcium reabsorption 💬

[1] PTH1R 💬

Teriparatide 💬

Teriparatide

[7] 46, 65, 68, 70, 71, 235, 274 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
68	Ossification of the ligamentum flavum;Ossification of ligamentum flavum;OLF;
70	Spinal stenosis;Extensive spinal canal stenosis;
71	Idiopathic osteonecrosis of the femoral head;Idiopathic femoral head necrosis;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
274	Osteogenesis Imperfecta;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Alfacalcidol 💬

Alfacalcidol

[8] 41, 46, 49, 50, 96, 107, 235, 238 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
96	Crohn disease;Terminal ileitis;
107	Juvenile idiopathic arthritis;JIA;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
238	Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;

Endocrine and other factor-regulated calcium reabsorption 💬

[1] VDR 💬

Calcitriol 💬

Calcitriol

[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬

Disease ID	Name
18	Spinocerebellar degeneration;SCD;
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
158	Tuberous sclerosis;Tuberous sclerosis complex;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
326	Osteopetrosis;

Mineral absorption 💬

[1] VDR 💬

Alfacalcidol 💬

Alfacalcidol

[8] 41, 46, 49, 50, 96, 107, 235, 238 💬

Disease ID	Name
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
96	Crohn disease;Terminal ileitis;
107	Juvenile idiopathic arthritis;JIA;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
238	Vitamin D-resistant rickets;VDRR;Vitamin D-resistant osteomalacia;VDRO;FGF23-related hypophosphatemic disease;FGF23-related hypophosphatemia;Hypophosphatemic rickets/osteomalacia;

Mineral absorption 💬

[1] VDR 💬

Calcitriol 💬

Calcitriol

[9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬

Disease ID	Name
18	Spinocerebellar degeneration;SCD;
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
96	Crohn disease;Terminal ileitis;
158	Tuberous sclerosis;Tuberous sclerosis complex;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
326	Osteopetrosis;

Neuroactive ligand-receptor interaction 💬

[1] NR3C1 💬

Betamethasone 💬

Betamethasone

[8] 2 , 28, 46, 65, 83, 90, 96, 235 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
28	Systemic amyloidosis;AL amyloidosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
83	Addison disease;Primary chronic adrenocortical insufficiency;
90	Retinitis pigmentosa;
96	Crohn disease;Terminal ileitis;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;

Neuroactive ligand-receptor interaction 💬

[1] NR3C1 💬

Dexamethasone 💬

Dexamethasone

[22] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299💬 ...

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
16	Crow-Fukase syndrome;POEMS syndrome;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
64	Thrombotic thrombocytopenic purpura;TTP;
65	Primary immunodeficiency;
70	Spinal stenosis;Extensive spinal canal stenosis;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
162	Pemphigoid;
222	Primary nephrotic syndrome;
235	Hypoparathyroidism;Accessory thyroid hypergasia disease;
257	Hepatic glycogenosis;Liver glycogenosis;Hepatic glycogen storage disease;Liver glycogen storage disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
296	Biliary atresia;
299	Cystic fibrosis;

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