Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholism 💬
 [1] DRD2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
2 Alzheimer disease 💬
 [3] CHRM1, CHRM3, CHRM5 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
3 Biosynthesis of cofactors 💬
 [1] ALAS1 💬 Givosiran 💬 Givosiran [1] 254 💬
4 Biosynthesis of cofactors 💬
 [2] ALAS1, ALAS2 💬 Hemin 💬 Hemin [1] 254 💬
5 Calcium signaling pathway 💬
 [8] CHRM1, CHRM2, CHRM3, CHRM5, HRH1, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
6 Calcium signaling pathway 💬
 [1] HRH2 💬 Cimetidine 💬 Cimetidine [2]  2 , 254 💬
7 cAMP signaling pathway 💬
 [3] CHRM1, CHRM2, DRD2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
8 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
9 Chemical carcinogenesis - reactive oxygen species 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
10 Cholinergic synapse 💬
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
11 Cocaine addiction 💬
 [1] DRD2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
12 Dopaminergic synapse 💬
 [1] DRD2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
13 Ferroptosis 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
14 Fluid shear stress and atherosclerosis 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
15 Gap junction 💬
 [4] DRD2, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
16 Gastric acid secretion 💬
 [1] CHRM3 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
17 Gastric acid secretion 💬
 [1] HRH2 💬 Cimetidine 💬 Cimetidine [2]  2 , 254 💬
18 Glycine, serine and threonine metabolism 💬
 [1] ALAS1 💬 Givosiran 💬 Givosiran [1] 254 💬
19 Glycine, serine and threonine metabolism 💬
 [2] ALAS1, ALAS2 💬 Hemin 💬 Hemin [1] 254 💬
20 Hepatocellular carcinoma 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
21 HIF-1 signaling pathway 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
22 Inflammatory mediator regulation of TRP channels 💬
 [4] HRH1, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
23 Insulin secretion 💬
 [1] CHRM3 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
24 Melanogenesis 💬
 [1] MC1R 💬 Afamelanotide 💬 Afamelanotide [3] 159, 161, 254 💬
25 Metabolic pathways 💬
 [1] ALAS1 💬 Givosiran 💬 Givosiran [1] 254 💬
26 Metabolic pathways 💬
 [2] ALAS1, ALAS2 💬 Hemin 💬 Hemin [1] 254 💬
27 Metabolic pathways 💬
 [2] HMOX1, HMOX2 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
28 MicroRNAs in cancer 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
29 Mineral absorption 💬
 [2] HMOX1, HMOX2 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
30 Neuroactive ligand-receptor interaction 💬
 [13] ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
31 Neuroactive ligand-receptor interaction 💬
 [1] HRH2 💬 Cimetidine 💬 Cimetidine [2]  2 , 254 💬
32 Neuroactive ligand-receptor interaction 💬
 [1] MC1R 💬 Afamelanotide 💬 Afamelanotide [3] 159, 161, 254 💬
33 Pancreatic secretion 💬
 [1] CHRM3 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
34 Parkinson disease 💬
 [1] DRD2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
35 Pathways in cancer 💬
 [1] HMOX1 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
36 Pathways of neurodegeneration - multiple diseases 💬
 [3] CHRM1, CHRM3, CHRM5 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
37 PI3K-Akt signaling pathway 💬
 [2] CHRM1, CHRM2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
38 Porphyrin metabolism 💬
 [1] ALAS1 💬 Givosiran 💬 Givosiran [1] 254 💬
39 Porphyrin metabolism 💬
 [2] ALAS1, ALAS2 💬 Hemin 💬 Hemin [1] 254 💬
40 Porphyrin metabolism 💬
 [2] HMOX1, HMOX2 💬 Stannsoporfin 💬 Stannsoporfin [1] 254 💬
41 Rap1 signaling pathway 💬
 [1] DRD2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
42 Regulation of actin cytoskeleton 💬
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
43 Salivary secretion 💬
 [1] CHRM3 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
44 Serotonergic synapse 💬
 [3] HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
45 Taste transduction 💬
 [1] CHRM3 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬

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