Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adherens junction 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
2 Alcoholism 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
3 Alcoholism 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
4 Alcoholism 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
5 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
6 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
7 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
8 Alzheimer disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
9 Alzheimer disease 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
10 Amphetamine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
11 AMPK signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
12 AMPK signaling pathway 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
13 Amyotrophic lateral sclerosis 💬
 [6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
14 Apelin signaling pathway 💬
 [1] PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
15 Apelin signaling pathway 💬
 [1] PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
16 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
17 Autophagy - animal 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
18 Breast cancer 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
19 C-type lectin receptor signaling pathway 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
20 Calcium signaling pathway 💬
 [2] ADORA2A, PDE1B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
21 Calcium signaling pathway 💬
 [2] ADORA2A, PDE1B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
22 Calcium signaling pathway 💬
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
23 cAMP signaling pathway 💬
 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
24 cAMP signaling pathway 💬
 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
25 cAMP signaling pathway 💬
 [1] GHSR 💬 Macimorelin 💬 Macimorelin [1] 78 💬
26 cAMP signaling pathway 💬
 [1] GLP1R 💬 Exenatide 💬 Exenatide [6]  6 , 17, 72, 78, 193, 233 💬
27 cAMP signaling pathway 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
28 cAMP signaling pathway 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
29 cAMP signaling pathway 💬
 [3] SSTR1, SSTR2, SSTR5 💬 Somatostatin 💬 Somatostatin [2] 67, 78 💬
30 cGMP-PKG signaling pathway 💬
 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
31 cGMP-PKG signaling pathway 💬
 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
32 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Clonidine 💬 Clonidine [4]  6 , 65, 70, 78 💬
33 Chemical carcinogenesis - DNA adducts 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
34 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone 💬 Testosterone [8]  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
35 Cholinergic synapse 💬
 [1] ACHE 💬 Donepezil 💬 Donepezil [9]  5 ,  6 , 13, 46, 78, 124, 127, 156, 206 💬
36 Circadian entrainment 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
37 Circadian entrainment 💬
 [2] MTNR1A, MTNR1B 💬 Melatonin 💬 Melatonin [12]  6 ,  8 , 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
38 Cocaine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
39 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
40 Cushing syndrome 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
41 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 Lonapegsomatropin 💬 Lonapegsomatropin [1] 78 💬
42 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
43 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 Pegvisomant 💬 Pegvisomant [2] 78, 265 💬
44 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 Somapacitan 💬 Somapacitan [2] 78, 195 💬
45 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 Somavaratan 💬 Somavaratan [1] 78 💬
46 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
47 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
48 Endocrine resistance 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
49 Endocytosis 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
50 Estrogen signaling pathway 💬
 [1] OPRM1 💬 Tramadol 💬 Tramadol [5] 46, 70, 78, 226, 271 💬
51 Focal adhesion 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
52 FoxO signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
53 Gastric acid secretion 💬
 [1] SSTR2 💬 Somatostatin 💬 Somatostatin [2] 67, 78 💬
54 Glioma 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
55 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
56 Glucagon signaling pathway 💬
 [1] PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
57 Glutamatergic synapse 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
58 Glycerophospholipid metabolism 💬
 [1] ACHE 💬 Donepezil 💬 Donepezil [9]  5 ,  6 , 13, 46, 78, 124, 127, 156, 206 💬
59 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 Lonapegsomatropin 💬 Lonapegsomatropin [1] 78 💬
60 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
61 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 Pegvisomant 💬 Pegvisomant [2] 78, 265 💬
62 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 Somapacitan 💬 Somapacitan [2] 78, 195 💬
63 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 Somavaratan 💬 Somavaratan [1] 78 💬
64 Growth hormone synthesis, secretion and action 💬
 [1] GHRHR 💬 Somatorelin 💬 Somatorelin [2] 13, 78 💬
65 Growth hormone synthesis, secretion and action 💬
 [1] GHRHR 💬 Tesamorelin 💬 Tesamorelin [2] 78, 265 💬
66 Growth hormone synthesis, secretion and action 💬
 [1] GHSR 💬 Macimorelin 💬 Macimorelin [1] 78 💬
67 Growth hormone synthesis, secretion and action 💬
 [4] SSTR1, SSTR2, SSTR3, SSTR5 💬 Somatostatin 💬 Somatostatin [2] 67, 78 💬
68 Hepatocellular carcinoma 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
69 HIF-1 signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
70 Human cytomegalovirus infection 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
71 Human papillomavirus infection 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
72 Huntington disease 💬
 [2] GRIN1, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
73 Huntington disease 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
74 IL-17 signaling pathway 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
75 Insulin secretion 💬
 [1] GLP1R 💬 Exenatide 💬 Exenatide [6]  6 , 17, 72, 78, 193, 233 💬
76 Insulin signaling pathway 💬
 [1] PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
77 Insulin signaling pathway 💬
 [1] PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
78 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Lonapegsomatropin 💬 Lonapegsomatropin [1] 78 💬
79 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
80 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Pegvisomant 💬 Pegvisomant [2] 78, 265 💬
81 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Somapacitan 💬 Somapacitan [2] 78, 195 💬
82 JAK-STAT signaling pathway 💬
 [1] GHR 💬 Somavaratan 💬 Somavaratan [1] 78 💬
83 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
84 Leishmaniasis 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
85 Lipid and atherosclerosis 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
86 Long-term depression 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
87 Long-term potentiation 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
88 Longevity regulating pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
89 Longevity regulating pathway 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
90 Longevity regulating pathway - multiple species 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
91 MAPK signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
92 Melanoma 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
93 Metabolic pathways 💬
 [1] CYP19A1 💬 Anastrozole 💬 Anastrozole [3] 78, 86, 193 💬
94 Metabolic pathways 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
95 Metabolic pathways 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
96 Metabolic pathways 💬
 [2] PTGS1, PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
97 MicroRNAs in cancer 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
98 Morphine addiction 💬
 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
99 Morphine addiction 💬
 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
100 Morphine addiction 💬
 [1] OPRM1 💬 Tramadol 💬 Tramadol [5] 46, 70, 78, 226, 271 💬
101 mTOR signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
102 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
103 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
104 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Clonidine 💬 Clonidine [4]  6 , 65, 70, 78 💬
105 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 Lonapegsomatropin 💬 Lonapegsomatropin [1] 78 💬
106 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
107 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 Pegvisomant 💬 Pegvisomant [2] 78, 265 💬
108 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 Somapacitan 💬 Somapacitan [2] 78, 195 💬
109 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 Somavaratan 💬 Somavaratan [1] 78 💬
110 Neuroactive ligand-receptor interaction 💬
 [1] GHRHR 💬 Somatorelin 💬 Somatorelin [2] 13, 78 💬
111 Neuroactive ligand-receptor interaction 💬
 [1] GHRHR 💬 Tesamorelin 💬 Tesamorelin [2] 78, 265 💬
112 Neuroactive ligand-receptor interaction 💬
 [1] GHSR 💬 Macimorelin 💬 Macimorelin [1] 78 💬
113 Neuroactive ligand-receptor interaction 💬
 [1] GLP1R 💬 Exenatide 💬 Exenatide [6]  6 , 17, 72, 78, 193, 233 💬
114 Neuroactive ligand-receptor interaction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
115 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
116 Neuroactive ligand-receptor interaction 💬
 [2] MTNR1A, MTNR1B 💬 Melatonin 💬 Melatonin [12]  6 ,  8 , 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
117 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 Hydrocortisone 💬 Hydrocortisone [10]  6 , 41, 46, 53, 75, 78, 81, 83, 97, 299 💬
118 Neuroactive ligand-receptor interaction 💬
 [1] OPRM1 💬 Tramadol 💬 Tramadol [5] 46, 70, 78, 226, 271 💬
119 Neuroactive ligand-receptor interaction 💬
 [5] SSTR1, SSTR2, SSTR3, SSTR4, SSTR5 💬 Somatostatin 💬 Somatostatin [2] 67, 78 💬
120 Neuroactive ligand-receptor interaction 💬
 [2] THRA, THRB 💬 Levothyroxine 💬 Levothyroxine [5] 19, 49, 78, 80, 222 💬
121 Neuroactive ligand-receptor interaction 💬
 [2] THRA, THRB 💬 Liothyronine 💬 Liothyronine [4] 13, 78, 210, 212 💬
122 Neuroactive ligand-receptor interaction 💬
 [2] THRA, THRB 💬 Tiratricol 💬 Tiratricol [2] 78, 139 💬
123 NF-kappa B signaling pathway 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
124 Nicotine addiction 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
125 Non-alcoholic fatty liver disease 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
126 Olfactory transduction 💬
 [2] PDE1B, PDE2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
127 Olfactory transduction 💬
 [2] PDE1B, PDE2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
128 Oocyte meiosis 💬
 [1] AR 💬 Testosterone 💬 Testosterone [8]  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
129 Oocyte meiosis 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
130 Osteoclast differentiation 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
131 Ovarian steroidogenesis 💬
 [1] CYP19A1 💬 Anastrozole 💬 Anastrozole [3] 78, 86, 193 💬
132 Ovarian steroidogenesis 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
133 Ovarian steroidogenesis 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
134 Oxytocin signaling pathway 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
135 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
136 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
137 Parkinson disease 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
138 Parkinson disease 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
139 Pathways in cancer 💬
 [1] AR 💬 Testosterone 💬 Testosterone [8]  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
140 Pathways in cancer 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
141 Pathways in cancer 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
142 Pathways in cancer 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
143 Pathways of neurodegeneration - multiple diseases 💬
 [6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
144 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
145 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 Lonapegsomatropin 💬 Lonapegsomatropin [1] 78 💬
146 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 Pegvisomant 💬 Pegvisomant [2] 78, 265 💬
147 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 Somapacitan 💬 Somapacitan [2] 78, 195 💬
148 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 Somavaratan 💬 Somavaratan [1] 78 💬
149 PI3K-Akt signaling pathway 💬
 [2] GHR, IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
150 Platelet activation 💬
 [1] PTGS1 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
151 PPAR signaling pathway 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
152 Prion disease 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
153 Progesterone-mediated oocyte maturation 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
154 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
155 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
156 Prostate cancer 💬
 [1] AR 💬 Testosterone 💬 Testosterone [8]  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
157 Prostate cancer 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
158 Proteoglycans in cancer 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
159 Purine metabolism 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
160 Purine metabolism 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
161 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
162 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
163 Rap1 signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
164 Rap1 signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
165 Ras signaling pathway 💬
 [3] GRIN1, GRIN2A, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
166 Ras signaling pathway 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
167 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
168 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
169 Regulation of lipolysis in adipocytes 💬
 [2] PTGS1, PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
170 Renin secretion 💬
 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
171 Renin secretion 💬
 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
172 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
173 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
174 Serotonergic synapse 💬
 [1] SLC6A4 💬 Amitriptyline 💬 Amitriptyline [4] 78, 97, 226, 299 💬
175 Serotonergic synapse 💬
 [1] SLC6A4 💬 Fluoxetine 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
176 Signaling pathways regulating pluripotency of stem cells 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
177 Small cell lung cancer 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
178 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
179 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
180 Spinocerebellar ataxia 💬
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
181 Steroid hormone biosynthesis 💬
 [1] CYP19A1 💬 Anastrozole 💬 Anastrozole [3] 78, 86, 193 💬
182 Synaptic vesicle cycle 💬
 [2] SLC6A2, SLC6A4 💬 Amitriptyline 💬 Amitriptyline [4] 78, 97, 226, 299 💬
183 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Fluoxetine 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
184 Systemic lupus erythematosus 💬
 [2] GRIN2A, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
185 Taste transduction 💬
 [1] PDE1B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
186 Taste transduction 💬
 [1] PDE1B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
187 Thermogenesis 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
188 Thyroid cancer 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
189 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 Levothyroxine 💬 Levothyroxine [5] 19, 49, 78, 80, 222 💬
190 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 Liothyronine 💬 Liothyronine [4] 13, 78, 210, 212 💬
191 Thyroid hormone signaling pathway 💬
 [2] THRA, THRB 💬 Tiratricol 💬 Tiratricol [2] 78, 139 💬
192 TNF signaling pathway 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
193 Transcriptional misregulation in cancer 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
194 Transcriptional misregulation in cancer 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
195 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
196 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
197 VEGF signaling pathway 💬
 [1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬

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