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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Biosynthesis of cofactors 💬

[2] NQO1, VKORC1 💬

Warfarin 💬

Warfarin

[11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
91	Budd-Chiari syndrome;BCS;

Chemical carcinogenesis - reactive oxygen species 💬

[1] NQO1 💬

Warfarin 💬

Warfarin

[11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
91	Budd-Chiari syndrome;BCS;

Complement and coagulation cascades 💬

[1] F10 💬

Rivaroxaban 💬

Rivaroxaban

[4] 46, 49, 91, 210 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
91	Budd-Chiari syndrome;BCS;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Complement and coagulation cascades 💬

[1] F2 💬

Dabigatran 💬

Dabigatran

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Coronavirus disease - COVID-19 💬

[1] F2 💬

Dabigatran 💬

Dabigatran

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Fluid shear stress and atherosclerosis 💬

[1] NQO1 💬

Warfarin 💬

Warfarin

[11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
91	Budd-Chiari syndrome;BCS;

Hepatocellular carcinoma 💬

[1] NQO1 💬

Warfarin 💬

Warfarin

[11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
91	Budd-Chiari syndrome;BCS;

Metabolic pathways 💬

[2] NQO1, VKORC1 💬

Warfarin 💬

Warfarin

[11] 6 , 8 , 13, 19, 46, 49, 66, 85, 86, 88, 91 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
91	Budd-Chiari syndrome;BCS;

Neuroactive ligand-receptor interaction 💬

[1] F2 💬

Dabigatran 💬

Dabigatran

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Pathogenic Escherichia coli infection 💬

[1] F2 💬

Dabigatran 💬

Dabigatran

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

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