Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Aldosterone-regulated sodium reabsorption 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

[1] 299 💬

2

Aldosterone-regulated sodium reabsorption 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

3

Aldosterone-regulated sodium reabsorption 💬

[1] INSR 💬

Insulin detemir 💬

Insulin detemir

[1] 299 💬

4

Aldosterone-regulated sodium reabsorption 💬

[1] INSR 💬

Insulin glargine 💬

Name	Other Names
Insulin glargine	Insulin glargine (USAN/INN) Insulin glargine (genetical recombination) (JP18) Insulin glargine (genetical recombination) [Insulin glargin biosimilar 1] (JAN) Insulin glargine (genetical recombination) [Insulin glargin biosimilar 2] (JAN) Lantus (TN) BASAGLAR INSULIN GLARGINE SOLOSTAR LANTUS SOLOSTAR REZVOGLAR SEMGLEE TOUJEO TOUJEO MAX

Insulin glargine

[1] 299 💬

5

Aldosterone-regulated sodium reabsorption 💬

[1] INSR 💬

Insulin human 💬

[2] 96, 156 💬

6

Aldosterone-regulated sodium reabsorption 💬

[1] NR3C2 💬

Aldosterone 💬

[1] 222 💬

7

Aldosterone-regulated sodium reabsorption 💬

[1] NR3C2 💬

Eplerenone 💬

[4] 75, 113, 210, 215 💬

Disease ID	Name
75	Cushing disease;Cushing;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;

8

Aldosterone-regulated sodium reabsorption 💬

[1] NR3C2 💬

Fludrocortisone 💬

Fludrocortisone

[3] 6 , 17, 81 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
17	Multiple system atrophy;MSA-C;MSA-P;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;

9

Aldosterone-regulated sodium reabsorption 💬

[1] NR3C2 💬

Spironolactone 💬

[8] 46, 58, 67, 86, 113, 210, 218, 225 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
58	Hypertrophic cardiomyopathy;HCM;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;

10

Aldosterone-regulated sodium reabsorption 💬

[1] PIK3CA 💬

[1] 138 💬

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