Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Collecting duct acid secretion 💬

[2] ATP4A, ATP4B 💬

Dexlansoprazole 💬

Dexlansoprazole

[1] 98 💬

2

Collecting duct acid secretion 💬

[2] ATP4A, ATP4B 💬

Esomeprazole 💬

[8] 13, 46, 86, 98, 107, 113, 298, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
86	Pulmonary arterial hypertension;PAH;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

3

Collecting duct acid secretion 💬

[2] ATP4A, ATP4B 💬

Lansoprazole 💬

[7] 63, 71, 85, 98, 166, 222, 299 💬

Disease ID	Name
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
71	Idiopathic osteonecrosis of the femoral head;Idiopathic femoral head necrosis;
85	Idiopathic interstitial pneumonia;IIPs;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
166	Pseudoxanthoma elasticum;PXE;
222	Primary nephrotic syndrome;
299	Cystic fibrosis;

4

Collecting duct acid secretion 💬

[2] ATP4A, ATP4B 💬

Omeprazole 💬

[14] 6 , 8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
282	Congenital dyserythropoietic anemia;CDA;
294	Congenital diaphragmatic hernia;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

5

Collecting duct acid secretion 💬

[2] ATP4A, ATP4B 💬

Pantoprazole 💬

[2] 13, 65 💬

6

Collecting duct acid secretion 💬

[2] ATP4A, ATP4B 💬

Rabeprazole 💬

[2] 2 , 51 💬

7

Collecting duct acid secretion 💬

[2] ATP4A, ATP4B 💬

Vonoprazan 💬

[2] 63, 98 💬

Disease ID	Name
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;

8

Collecting duct acid secretion 💬

[1] CA2 💬

Acetazolamide 💬

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

9

Collecting duct acid secretion 💬

[1] CA2 💬

Dichlorphenamide 💬

[1] 114 💬

10

Collecting duct acid secretion 💬

[1] CA2 💬

Dorzolamide 💬

[1] 90 💬

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