Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
2 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
3 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Candesartan 💬 Candesartan [2] 58, 67 💬
4 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil [1] 67 💬
5 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
6 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
7 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
8 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Telmisartan 💬 Telmisartan [2] 66, 67 💬
9 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
10 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
11 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
12 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
13 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
14 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
15 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
16 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
17 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
18 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
19 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
20 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
21 Cortisol synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Flunarizine 💬 Flunarizine [1] 149 💬
22 Cortisol synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
23 Cortisol synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Zonisamide 💬 Zonisamide [1]  6  💬
24 Cortisol synthesis and secretion 💬
 [3] CYP11A1, CYP11B1, CYP17A1 💬 Levoketoconazole 💬 Levoketoconazole [1] 75 💬
25 Cortisol synthesis and secretion 💬
 [1] CYP11B1 💬 Metyrapone 💬 Metyrapone [1] 75 💬
26 Cortisol synthesis and secretion 💬
 [1] CYP17A1 💬 Ketoconazole 💬 Ketoconazole [3]  8 , 13, 75 💬
27 Cortisol synthesis and secretion 💬
 [1] KCNA4 💬 Amifampridine 💬 Amifampridine [3]  3 , 11, 12 💬
28 Cortisol synthesis and secretion 💬
 [1] KCNA4 💬 Dalfampridine 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
29 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Corticotropin 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
30 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
31 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
32 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
33 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
34 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
35 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬