Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 Diazoxide 💬 Diazoxide [2] 13, 193 💬
2 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 Minoxidil 💬 Minoxidil [1] 179 💬
3 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 Repaglinide 💬 Repaglinide [4]  6 , 21, 46, 299 💬
4 Insulin secretion 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 Digitoxin 💬 Digitoxin [1] 299 💬
5 Insulin secretion 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 Digoxin 💬 Digoxin [3]  8 , 46, 210 💬
6 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
7 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
8 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
9 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
10 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
11 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
12 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
13 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
14 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
15 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
16 Insulin secretion 💬
 [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM3 💬 Propiverine 💬 Propiverine [1] 226 💬
17 Insulin secretion 💬
 [1] CHRM3 💬 Atropine 💬 Atropine [2]  2 , 299 💬
18 Insulin secretion 💬
 [1] CHRM3 💬 Blarcamesine 💬 Blarcamesine [1] 156 💬
19 Insulin secretion 💬
 [1] CHRM3 💬 Cevimeline 💬 Cevimeline [1] 53 💬
20 Insulin secretion 💬
 [1] CHRM3 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
21 Insulin secretion 💬
 [1] CHRM3 💬 Darifenacin 💬 Darifenacin [2]  6 , 13 💬
22 Insulin secretion 💬
 [1] CHRM3 💬 Fesoterodine 💬 Fesoterodine [1]  6  💬
23 Insulin secretion 💬
 [1] CHRM3 💬 Oxybutynin 💬 Oxybutynin [3]  6 , 13, 53 💬
24 Insulin secretion 💬
 [1] CHRM3 💬 Pilocarpine 💬 Pilocarpine [3]  6 , 53, 299 💬
25 Insulin secretion 💬
 [1] CHRM3 💬 Scopolamine 💬 Scopolamine [1]  2  💬
26 Insulin secretion 💬
 [1] CHRM3 💬 Solifenacin 💬 Solifenacin [3]  6 , 13, 53 💬
27 Insulin secretion 💬
 [1] CHRM3 💬 Tolterodine 💬 Tolterodine [2] 17, 53 💬
28 Insulin secretion 💬
 [1] CHRM3 💬 Trihexyphenidyl 💬 Trihexyphenidyl [2]  5 ,  6  💬
29 Insulin secretion 💬
 [1] CHRM3 💬 Tropicamide 💬 Tropicamide [1]  6  💬
30 Insulin secretion 💬
 [1] GLP1R 💬 Dulaglutide 💬 Dulaglutide [2] 13, 299 💬
31 Insulin secretion 💬
 [1] GLP1R 💬 Exenatide 💬 Exenatide [6]  6 , 17, 72, 78, 193, 233 💬
32 Insulin secretion 💬
 [1] GLP1R 💬 Liraglutide 💬 Liraglutide [3]  6 , 75, 193 💬
33 Insulin secretion 💬
 [1] GLP1R 💬 Lixisenatide 💬 Lixisenatide [1]  6  💬
34 Insulin secretion 💬
 [1] GLP1R 💬 Semaglutide 💬 Semaglutide [1]  6  💬
35 Insulin secretion 💬
 [1] GLP1R 💬 Tirzepatide 💬 Tirzepatide [1] 233 💬
36 Insulin secretion 💬
 [1] KCNJ11 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
37 Insulin secretion 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
38 Insulin secretion 💬
 [1] SNAP25 💬 Botulinum toxin type A 💬 Botulinum toxin type A [14]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬
39 Insulin secretion 💬
 [1] SNAP25 💬 Rimabotulinumtoxin B 💬 Botulinum toxin type B [4]  2 ,  6 , 13, 51 💬