Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Metabolic pathways 💬

[1] ABAT 💬

Vigabatrin 💬

[2] 145, 158 💬

2

Metabolic pathways 💬

[4] ABAT, ALDH5A1, GAD1, GAD2 💬

Valproic acid 💬

[14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
5	Progressive supranuclear palsy;PSP;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
90	Retinitis pigmentosa;
102	Rubinstein-Taybi syndrome;RSTS;Histone acetylation disorder;
127	Frontotemporal lobar degeneration;
222	Primary nephrotic syndrome;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

3

Metabolic pathways 💬

[3] ADH1A, ADH1B, ADH1C 💬

Fomepizole 💬

[1] 301 💬

4

Metabolic pathways 💬

[1] ALAS1 💬

[1] 254 💬

5

Metabolic pathways 💬

[2] ALAS1, ALAS2 💬

Hemin 💬

[1] 254 💬

6

Metabolic pathways 💬

[1] ALOX5 💬

[1] 113 💬

7

Metabolic pathways 💬

[1] ALOX5 💬

[3] 85, 160, 164 💬

8

Metabolic pathways 💬

[1] ALPL 💬

Asfotase alfa 💬

[1] 172 💬

9

Metabolic pathways 💬

[5] AMY2A, AMY2B, GAA, GANC, MGAM 💬

[1] 298 💬

10

Metabolic pathways 💬

[1] ANPEP 💬

[1] 86 💬

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