Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Renal cell carcinoma 💬

[1] BRAF 💬

Dabrafenib 💬

[1] 34 💬

2

Renal cell carcinoma 💬

[2] BRAF, RAF1 💬

[2] 34, 86 💬

3

Renal cell carcinoma 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

[1] 34 💬

4

Renal cell carcinoma 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

[1] 280 💬

5

Renal cell carcinoma 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

[1] 34 💬

6

Renal cell carcinoma 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

[1] 34 💬

7

Renal cell carcinoma 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

8

Renal cell carcinoma 💬

[1] MET 💬

Cabozantinib 💬

[1] 34 💬

9

Renal cell carcinoma 💬

[1] PIK3CA 💬

[1] 138 💬

10

Renal cell carcinoma 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

[2] 53, 65 💬

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