Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholism 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
2 Alcoholism 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
3 Alcoholism 💬
 [1] ADORA2A 💬 Istradefylline 💬 Istradefylline [1]  6  💬
4 Alcoholism 💬
 [1] ADORA2A 💬 Preladenant 💬 Preladenant [1]  6  💬
5 Alcoholism 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
6 Alcoholism 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
7 Alcoholism 💬
 [1] ADORA2A 💬 Tozadenant 💬 Tozadenant [1]  6  💬
8 Alcoholism 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
9 Alcoholism 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬
10 Calcium signaling pathway 💬
 [1] ADORA2A 💬 Istradefylline 💬 Istradefylline [1]  6  💬
11 Calcium signaling pathway 💬
 [1] ADORA2A 💬 Preladenant 💬 Preladenant [1]  6  💬
12 Calcium signaling pathway 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
13 Calcium signaling pathway 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
14 Calcium signaling pathway 💬
 [1] ADORA2A 💬 Tozadenant 💬 Tozadenant [1]  6  💬
15 Calcium signaling pathway 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
16 Calcium signaling pathway 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬
17 Calcium signaling pathway 💬
 [2] ADORA2A, PDE1B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
18 Calcium signaling pathway 💬
 [2] ADORA2A, PDE1B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
19 cAMP signaling pathway 💬
 [2] ADORA1, ADORA2A 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
20 cAMP signaling pathway 💬
 [2] ADORA1, ADORA2A 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬
21 cAMP signaling pathway 💬
 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
22 cAMP signaling pathway 💬
 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
23 cAMP signaling pathway 💬
 [1] ADORA2A 💬 Istradefylline 💬 Istradefylline [1]  6  💬
24 cAMP signaling pathway 💬
 [1] ADORA2A 💬 Preladenant 💬 Preladenant [1]  6  💬
25 cAMP signaling pathway 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
26 cAMP signaling pathway 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
27 cAMP signaling pathway 💬
 [1] ADORA2A 💬 Tozadenant 💬 Tozadenant [1]  6  💬
28 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
29 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
30 Neuroactive ligand-receptor interaction 💬
 [4] ADORA1, ADORA2A, ADORA2B, ADORA3 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
31 Neuroactive ligand-receptor interaction 💬
 [4] ADORA1, ADORA2A, ADORA2B, ADORA3 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬
32 Neuroactive ligand-receptor interaction 💬
 [1] ADORA2A 💬 Istradefylline 💬 Istradefylline [1]  6  💬
33 Neuroactive ligand-receptor interaction 💬
 [1] ADORA2A 💬 Preladenant 💬 Preladenant [1]  6  💬
34 Neuroactive ligand-receptor interaction 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
35 Neuroactive ligand-receptor interaction 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
36 Neuroactive ligand-receptor interaction 💬
 [1] ADORA2A 💬 Tozadenant 💬 Tozadenant [1]  6  💬
37 Parkinson disease 💬
 [1] ADORA2A 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
38 Parkinson disease 💬
 [1] ADORA2A 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬
39 Parkinson disease 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
40 Parkinson disease 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
41 Parkinson disease 💬
 [1] ADORA2A 💬 Istradefylline 💬 Istradefylline [1]  6  💬
42 Parkinson disease 💬
 [1] ADORA2A 💬 Preladenant 💬 Preladenant [1]  6  💬
43 Parkinson disease 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
44 Parkinson disease 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
45 Parkinson disease 💬
 [1] ADORA2A 💬 Tozadenant 💬 Tozadenant [1]  6  💬
46 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
47 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
48 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 Istradefylline 💬 Istradefylline [1]  6  💬
49 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 Preladenant 💬 Preladenant [1]  6  💬
50 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
51 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
52 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 Tozadenant 💬 Tozadenant [1]  6  💬
53 Rap1 signaling pathway 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
54 Rap1 signaling pathway 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬
55 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
56 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
57 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Istradefylline 💬 Istradefylline [1]  6  💬
58 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Preladenant 💬 Preladenant [1]  6  💬
59 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
60 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Regadenoson 💬 Regadenoson [1] 58 💬
61 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 Tozadenant 💬 Tozadenant [1]  6  💬
62 Vascular smooth muscle contraction 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬
63 Vascular smooth muscle contraction 💬
 [2] ADORA2A, ADORA2B 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬

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