Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

cAMP signaling pathway 💬

[2] GABBR1, GABBR2 💬

Arbaclofen 💬

[2] 13, 206 💬

2

cAMP signaling pathway 💬

[2] GABBR1, GABBR2 💬

Arbaclofen placarbil 💬

Arbaclofen Placarbil

[1] 13 💬

3

cAMP signaling pathway 💬

[2] GABBR1, GABBR2 💬

[8] 2 , 10, 13, 18, 65, 70, 149, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
10	Charcot-Marie-Tooth disease;CMT;
13	Multiple sclerosis/Neuromyelitis optica;
18	Spinocerebellar degeneration;SCD;
65	Primary immunodeficiency;
70	Spinal stenosis;Extensive spinal canal stenosis;
149	Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
206	Fragile X syndrome;

4

cAMP signaling pathway 💬

[2] GABBR1, GABBR2 💬

Valiloxybate 💬

[1] 6 💬

5

Estrogen signaling pathway 💬

[2] GABBR1, GABBR2 💬

Arbaclofen 💬

[2] 13, 206 💬

6

Estrogen signaling pathway 💬

[2] GABBR1, GABBR2 💬

Arbaclofen placarbil 💬

Arbaclofen Placarbil

[1] 13 💬

7

Estrogen signaling pathway 💬

[2] GABBR1, GABBR2 💬

[8] 2 , 10, 13, 18, 65, 70, 149, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
10	Charcot-Marie-Tooth disease;CMT;
13	Multiple sclerosis/Neuromyelitis optica;
18	Spinocerebellar degeneration;SCD;
65	Primary immunodeficiency;
70	Spinal stenosis;Extensive spinal canal stenosis;
149	Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;
206	Fragile X syndrome;

8

Estrogen signaling pathway 💬

[2] GABBR1, GABBR2 💬

Valiloxybate 💬

[1] 6 💬

9

GABAergic synapse 💬

[2] GABBR1, GABBR2 💬

Arbaclofen 💬

[2] 13, 206 💬

10

GABAergic synapse 💬

[2] GABBR1, GABBR2 💬

Arbaclofen placarbil 💬

Arbaclofen Placarbil

[1] 13 💬

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