Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Amphetamine addiction 💬
 [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
2 Amphetamine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
3 Amphetamine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
4 Amphetamine addiction 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
5 Amyotrophic lateral sclerosis 💬
 [2] GRIA1, GRIA2 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
6 Amyotrophic lateral sclerosis 💬
 [2] GRIA1, GRIA2 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
7 Amyotrophic lateral sclerosis 💬
 [2] GRIA1, GRIA2 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
8 Amyotrophic lateral sclerosis 💬
 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
9 cAMP signaling pathway 💬
 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
10 cAMP signaling pathway 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
11 cAMP signaling pathway 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
12 cAMP signaling pathway 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
13 Circadian entrainment 💬
 [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
14 Circadian entrainment 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
15 Circadian entrainment 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
16 Circadian entrainment 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
17 Dopaminergic synapse 💬
 [7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
18 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
19 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
20 Dopaminergic synapse 💬
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
21 Glutamatergic synapse 💬
 [11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
22 Glutamatergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
23 Glutamatergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
24 Glutamatergic synapse 💬
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
25 Huntington disease 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
26 Huntington disease 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
27 Huntington disease 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
28 Huntington disease 💬
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
29 Long-term depression 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
30 Long-term depression 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
31 Long-term depression 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
32 Long-term depression 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
33 Long-term potentiation 💬
 [3] CACNA1C, GRIA1, GRIA2 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
34 Long-term potentiation 💬
 [2] GRIA1, GRIA2 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
35 Long-term potentiation 💬
 [2] GRIA1, GRIA2 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
36 Long-term potentiation 💬
 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
37 Neuroactive ligand-receptor interaction 💬
 [25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
38 Neuroactive ligand-receptor interaction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
39 Neuroactive ligand-receptor interaction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
40 Neuroactive ligand-receptor interaction 💬
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
41 Nicotine addiction 💬
 [20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
42 Nicotine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
43 Nicotine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
44 Nicotine addiction 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
45 Pathways of neurodegeneration - multiple diseases 💬
 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
46 Pathways of neurodegeneration - multiple diseases 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
47 Pathways of neurodegeneration - multiple diseases 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
48 Pathways of neurodegeneration - multiple diseases 💬
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
49 Retrograde endocannabinoid signaling 💬
 [24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
50 Retrograde endocannabinoid signaling 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
51 Retrograde endocannabinoid signaling 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
52 Retrograde endocannabinoid signaling 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
53 Spinocerebellar ataxia 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬
54 Spinocerebellar ataxia 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬
55 Spinocerebellar ataxia 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
56 Spinocerebellar ataxia 💬
 [8] GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬

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