Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

cGMP-PKG signaling pathway 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

[1] 58 💬

2

cGMP-PKG signaling pathway 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

3

Circadian entrainment 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

[1] 58 💬

4

Circadian entrainment 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

5

Gap junction 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

[1] 58 💬

6

Gap junction 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

7

Long-term depression 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

[1] 58 💬

8

Long-term depression 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

9

Metabolic pathways 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

[1] 58 💬

10

Metabolic pathways 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

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