Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

cAMP signaling pathway 💬

[2] HTR1B, HTR1D 💬

Zolmitriptan 💬

[1] 6 💬

2

cAMP signaling pathway 💬

[1] HTR1D 💬

Fenfluramine 💬

[4] 140, 144, 145, 149 💬

Disease ID	Name
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
145	West syndrome;Infantile spasm;
149	Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;

3

Neuroactive ligand-receptor interaction 💬

[2] HTR1B, HTR1D 💬

Zolmitriptan 💬

[1] 6 💬

4

Neuroactive ligand-receptor interaction 💬

[3] HTR1D, HTR2A, HTR2C 💬

Fenfluramine 💬

[4] 140, 144, 145, 149 💬

Disease ID	Name
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
145	West syndrome;Infantile spasm;
149	Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;

5

Serotonergic synapse 💬

[2] HTR1B, HTR1D 💬

Zolmitriptan 💬

[1] 6 💬

6

Serotonergic synapse 💬

[4] HTR1D, HTR2A, HTR2C, SLC6A4 💬

Fenfluramine 💬

[4] 140, 144, 145, 149 💬

Disease ID	Name
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
145	West syndrome;Infantile spasm;
149	Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;

7

Taste transduction 💬

[2] HTR1B, HTR1D 💬

Zolmitriptan 💬

[1] 6 💬

8

Taste transduction 💬

[1] HTR1D 💬

Fenfluramine 💬

[4] 140, 144, 145, 149 💬

Disease ID	Name
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
145	West syndrome;Infantile spasm;
149	Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;

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