Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Coronavirus disease - COVID-19 💬

[2] IFNAR1, IFNAR2 💬

Anifrolumab 💬

[3] 46, 49, 53 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;

2

Coronavirus disease - COVID-19 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa 💬

Interferon alfa

[6] 13, 25, 26, 28, 56, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
56	Behcet disease;Behçet disease;BD;
96	Crohn disease;Terminal ileitis;

3

Coronavirus disease - COVID-19 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa-2a 💬

Interferon alfa-2a

[1] 56 💬

4

Coronavirus disease - COVID-19 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa-2b 💬

Interferon alfa-2b

[2] 25, 34 💬

5

Coronavirus disease - COVID-19 💬

[2] IFNAR1, IFNAR2 💬

Interferon beta-1a 💬

Interferon beta-1a

[4] 13, 26, 96, 97 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;

6

Coronavirus disease - COVID-19 💬

[2] IFNAR1, IFNAR2 💬

Interferon beta-1b 💬

Interferon beta-1b

[1] 13 💬

7

Coronavirus disease - COVID-19 💬

[2] IFNAR1, IFNAR2 💬

Peginterferon beta-1a 💬

Peginterferon beta-1a

[1] 13 💬

8

Cytokine-cytokine receptor interaction 💬

[2] IFNAR1, IFNAR2 💬

Anifrolumab 💬

[3] 46, 49, 53 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;

9

Cytokine-cytokine receptor interaction 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa 💬

Interferon alfa

[6] 13, 25, 26, 28, 56, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
56	Behcet disease;Behçet disease;BD;
96	Crohn disease;Terminal ileitis;

10

Cytokine-cytokine receptor interaction 💬

[2] IFNAR1, IFNAR2 💬

Interferon alfa-2a 💬

Interferon alfa-2a

[1] 56 💬

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