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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

AGE-RAGE signaling pathway in diabetic complications 💬

[5] CCL2, IL1A, IL1B, IL6, TNF 💬

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

AGE-RAGE signaling pathway in diabetic complications 💬

[1] IL1A 💬

Bermekimab 💬

Bermekimab

[1] 51 💬

AGE-RAGE signaling pathway in diabetic complications 💬

[2] IL1A, IL1B 💬

Rilonacept 💬

Rilonacept

[4] 51, 106, 107, 266 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
106	Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome;
107	Juvenile idiopathic arthritis;JIA;
266	Familial mediterranean fever;

Alzheimer disease 💬

[1] IL1A 💬

Bermekimab 💬

Bermekimab

[1] 51 💬

Alzheimer disease 💬

[2] IL1A, IL1B 💬

Rilonacept 💬

Rilonacept

[4] 51, 106, 107, 266 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
106	Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome;
107	Juvenile idiopathic arthritis;JIA;
266	Familial mediterranean fever;

Alzheimer disease 💬

[4] IL1A, IL1B, IL6, TNF 💬

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

Cellular senescence 💬

[1] IL1A 💬

Bermekimab 💬

Bermekimab

[1] 51 💬

Cellular senescence 💬

[1] IL1A 💬

Rilonacept 💬

Rilonacept

[4] 51, 106, 107, 266 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
106	Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome;
107	Juvenile idiopathic arthritis;JIA;
266	Familial mediterranean fever;

Cellular senescence 💬

[2] IL1A, IL6 💬

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

Cytokine-cytokine receptor interaction 💬

[6] CCL2, IL10, IL1A, IL1B, IL6, TNF 💬

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

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