Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Acute myeloid leukemia 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

[1] 34 💬

2

Acute myeloid leukemia 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

[1] 280 💬

3

Acute myeloid leukemia 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

[1] 34 💬

4

Acute myeloid leukemia 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

[1] 34 💬

5

Acute myeloid leukemia 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

6

Alcoholism 💬

[1] MAP2K1 💬

Binimetinib 💬

[1] 34 💬

7

Alcoholism 💬

[1] MAP2K1 💬

Cobimetinib 💬

[1] 280 💬

8

Alcoholism 💬

[1] MAP2K1 💬

Mirdametinib 💬

[1] 34 💬

9

Alcoholism 💬

[1] MAP2K1 💬

Selumetinib 💬

[1] 34 💬

10

Alcoholism 💬

[1] MAP2K1 💬

Trametinib 💬

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

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