Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Aldosterone synthesis and secretion 💬

[1] PDE2A 💬

Aminophylline 💬

[1] 63 💬

2

Aldosterone synthesis and secretion 💬

[1] PDE2A 💬

Bucladesine 💬

[1] 246 💬

3

Aldosterone synthesis and secretion 💬

[1] PDE2A 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

4

Aldosterone synthesis and secretion 💬

[1] PDE2A 💬

Caffeine hydrate 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

5

Aldosterone synthesis and secretion 💬

[1] PDE2A 💬

[1] 226 💬

6

Aldosterone synthesis and secretion 💬

[1] PDE2A 💬

Theophylline 💬

[2] 236, 299 💬

7

Aldosterone synthesis and secretion 💬

[1] PDE2A 💬

Theophylline 💬

[2] 236, 299 💬

8

cGMP-PKG signaling pathway 💬

[4] ADORA1, PDE2A, PDE3A, PDE3B 💬

Aminophylline 💬

[1] 63 💬

9

cGMP-PKG signaling pathway 💬

[4] ADORA1, PDE2A, PDE3A, PDE3B 💬

Theophylline 💬

[2] 236, 299 💬

10

cGMP-PKG signaling pathway 💬

[4] ADORA1, PDE2A, PDE3A, PDE3B 💬

Theophylline 💬

[2] 236, 299 💬

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