Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

cAMP signaling pathway 💬

[8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Name	Full Name
ADORA1	adenosine A1 receptor
ADORA2A	adenosine A2a receptor
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

2

cAMP signaling pathway 💬

[8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Name	Full Name
ADORA1	adenosine A1 receptor
ADORA2A	adenosine A2a receptor
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D

Caffeine hydrate 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

3

cAMP signaling pathway 💬

[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Name	Full Name
ADORA1	adenosine A1 receptor
PDE10A	phosphodiesterase 10A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D

Aminophylline 💬

[1] 63 💬

4

cAMP signaling pathway 💬

[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Name	Full Name
ADORA1	adenosine A1 receptor
PDE10A	phosphodiesterase 10A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D

Theophylline 💬

[2] 236, 299 💬

5

cAMP signaling pathway 💬

[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Name	Full Name
ADORA1	adenosine A1 receptor
PDE10A	phosphodiesterase 10A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D

Theophylline 💬

[2] 236, 299 💬

6

cAMP signaling pathway 💬

[7] PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

Bucladesine 💬

[1] 246 💬

7

cAMP signaling pathway 💬

[7] PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬

[1] 226 💬

8

cAMP signaling pathway 💬

[2] PDE3A, PDE3B 💬

Cilostazol 💬

[3] 46, 51, 70 💬

9

cAMP signaling pathway 💬

[2] PDE3A, PDE3B 💬

Levosimendan 💬

[1] 2 💬

10

cAMP signaling pathway 💬

[2] PDE3A, PDE3B 💬

[1] 294 💬

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