Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 cAMP signaling pathway 💬
 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
2 cAMP signaling pathway 💬
 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
3 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Aminophylline 💬 Aminophylline [1] 63 💬
4 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
5 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
6 cAMP signaling pathway 💬
 [7] PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Bucladesine 💬 Bucladesine [1] 246 💬
7 cAMP signaling pathway 💬
 [7] PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Flavoxate 💬 Flavoxate [1] 226 💬
8 cAMP signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
9 cAMP signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
10 cAMP signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
11 cAMP signaling pathway 💬
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
12 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
13 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
14 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
15 cGMP-PKG signaling pathway 💬
 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
16 cGMP-PKG signaling pathway 💬
 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
17 cGMP-PKG signaling pathway 💬
 [3] PDE2A, PDE3A, PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
18 cGMP-PKG signaling pathway 💬
 [3] PDE2A, PDE3A, PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
19 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
20 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
21 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
22 cGMP-PKG signaling pathway 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
23 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
24 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
25 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
26 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
27 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
28 Metabolic pathways 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
29 Metabolic pathways 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
30 Metabolic pathways 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
31 Metabolic pathways 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
32 Metabolic pathways 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
33 Metabolic pathways 💬
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
34 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
35 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
36 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
37 Morphine addiction 💬
 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
38 Morphine addiction 💬
 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
39 Morphine addiction 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
40 Morphine addiction 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
41 Morphine addiction 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
42 Morphine addiction 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
43 Morphine addiction 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
44 Morphine addiction 💬
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
45 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
46 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
47 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
48 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
49 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
50 Purine metabolism 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
51 Purine metabolism 💬
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
52 Purine metabolism 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
53 Purine metabolism 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
54 Purine metabolism 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬
55 Purine metabolism 💬
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
56 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬
57 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
58 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬
59 Renin secretion 💬
 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
60 Renin secretion 💬
 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
61 Renin secretion 💬
 [5] PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬
62 Renin secretion 💬
 [5] PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬
63 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬
64 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬
65 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬
66 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬

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