Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Dopaminergic synapse 💬

[7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
GRIA1	glutamate ionotropic receptor AMPA type subunit 1
GRIA2	glutamate ionotropic receptor AMPA type subunit 2
GRIA3	glutamate ionotropic receptor AMPA type subunit 3
GRIA4	glutamate ionotropic receptor AMPA type subunit 4
SCN1A	sodium voltage-gated channel alpha subunit 1

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Dopaminergic synapse 💬

[3] KCNJ3, KCNJ5, SCN1A 💬

Amiodarone 💬

Amiodarone

[2] 28, 127 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Bupivacaine 💬

Bupivacaine

[8] 46, 51, 53, 70, 96, 168, 226, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;Terminal ileitis;
168	Ehlers-Danlos syndrome;EDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
298	Hereditary pancreatitis;Chronic pancreatitis;

Dopaminergic synapse 💬

[1] SCN1A 💬

Carbamazepine 💬

Carbamazepine

[3] 6 , 13, 231 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Cifenline 💬

Cibenzoline

[1] 58 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Eleclazine 💬

Eleclazine

[1] 58 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Flecainide 💬

Flecainide

[1] 6 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Lamotrigine 💬

Lamotrigine

[5] 13, 34, 38, 114, 144 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
114	Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;
144	Lennox-Gastaut syndrome;

Dopaminergic synapse 💬

[1] SCN1A 💬

Levobupivacaine 💬

Levobupivacaine

[1] 46 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Lidocaine 💬

Lidocaine

[13] 6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
107	Juvenile idiopathic arthritis;JIA;
168	Ehlers-Danlos syndrome;EDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Dopaminergic synapse 💬

[1] SCN1A 💬

Lidocaine hydrochloride monohydrate 💬

Name	Other Names
Lidocaine hydrochloride monohydrate	Lidocaine hydrochloride monohydrate Lidocaine (TN) Zingo (TN) 1% LIDOCAINE HCI 2% LIDOCAINE HCI LIDENZAL 1% LIDENZAL 2% LIDOCAINE HCI LIDOCAINE HCL LIDOCAINE HYDROCHLORIDE NA PRELIDOPINE PRE-OPERATIVE SYSTEM

Lidocaine

[13] 6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
107	Juvenile idiopathic arthritis;JIA;
168	Ehlers-Danlos syndrome;EDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

Dopaminergic synapse 💬

[1] SCN1A 💬

Mexiletine 💬

Mexiletine

[5] 1 , 2 , 10, 113, 114 💬

Disease ID	Name
1	Spinal and bulbar muscular atrophy;Spinobulbar muscular atrophy;SBMA;Kennedy disease;Kennedy-Alter-Sung syndrome;
2	Amyotrophic lateral sclerosis;ALS;
10	Charcot-Marie-Tooth disease;CMT;
113	Muscular dystrophy;
114	Non-dystrophic myotonia syndrome;Non-dystrophic Myotonia;

Dopaminergic synapse 💬

[1] SCN1A 💬

Oxcarbazepine 💬

Oxcarbazepine

[1] 13 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Oxybuprocaine 💬

Oxybuprocaine

[1] 6 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Phenytoin 💬

Phenytoin

[1] 13 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Quinidine 💬

Quinidine

[3] 2 , 8 , 13 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Ropivacaine 💬

Ropivacaine

[4] 22, 36, 46, 70 💬

Disease ID	Name
22	Moyamoya disease;Occlusive disease in circle of Willis;
36	Epidermolysis bullosa;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;

Dopaminergic synapse 💬

[1] SCN1A 💬

Rufinamide 💬

Rufinamide

[1] 144 💬

Dopaminergic synapse 💬

[1] SCN1A 💬

Zonisamide 💬

Zonisamide

[1] 6 💬