Target Gene/Pathway Pathway / Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Amyotrophic lateral sclerosis 💬

[6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D
SIGMAR1	sigma non-opioid intracellular receptor 1

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

2

Amyotrophic lateral sclerosis 💬

[1] SIGMAR1 💬

Blarcamesine 💬

[1] 156 💬

3

Amyotrophic lateral sclerosis 💬

[1] SIGMAR1 💬

Fenfluramine 💬

[4] 140, 144, 145, 149 💬

Disease ID	Name
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
145	West syndrome;Infantile spasm;
149	Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;

4

Pathways of neurodegeneration - multiple diseases 💬

[4] CHRM1, CHRM3, CHRM5, SIGMAR1 💬

Blarcamesine 💬

[1] 156 💬

5

Pathways of neurodegeneration - multiple diseases 💬

[6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D
SIGMAR1	sigma non-opioid intracellular receptor 1

Dextromethorphan 💬

Dextromethorphan

[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
156	Rett syndrome;

6

Pathways of neurodegeneration - multiple diseases 💬

[1] SIGMAR1 💬

Fenfluramine 💬

[4] 140, 144, 145, 149 💬

Disease ID	Name
140	Dorabe syndrome;Dravet syndrome;
144	Lennox-Gastaut syndrome;
145	West syndrome;Infantile spasm;
149	Hemiconvulsion hemiplegia epilepsy syndrome;One side convulsions;Hemiplegia;Epilepsy syndrome;