Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Platinum drug resistance 💬

[2] TOP2A, TOP2B 💬

Daunorubicin 💬

[1] 65 💬

2

Platinum drug resistance 💬

[2] TOP2A, TOP2B 💬

Dexrazoxane 💬

[1] 13 💬

3

Platinum drug resistance 💬

[2] TOP2A, TOP2B 💬

Doxorubicin 💬

[5] 26, 28, 34, 65, 331 💬

Disease ID	Name
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
65	Primary immunodeficiency;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

4

Platinum drug resistance 💬

[2] TOP2A, TOP2B 💬

[11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
60	Aplastic anemia;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

5

Platinum drug resistance 💬

[2] TOP2A, TOP2B 💬

Mitoxantrone 💬

[1] 13 💬

6

Platinum drug resistance 💬

[2] TOP2A, TOP2B 💬

Pixantrone 💬

[2] 11, 13 💬