Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 EGFR tyrosine kinase inhibitor resistance 💬
 [3] AXL, KDR, MET 💬 Cabozantinib 💬 Cabozantinib [1] 34 💬
2 EGFR tyrosine kinase inhibitor resistance 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
3 EGFR tyrosine kinase inhibitor resistance 💬
 [1] BRAF 💬 Dabrafenib 💬 Dabrafenib [1] 34 💬
4 EGFR tyrosine kinase inhibitor resistance 💬
 [4] BRAF, KDR, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
5 EGFR tyrosine kinase inhibitor resistance 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
6 EGFR tyrosine kinase inhibitor resistance 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
7 EGFR tyrosine kinase inhibitor resistance 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
8 EGFR tyrosine kinase inhibitor resistance 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
9 EGFR tyrosine kinase inhibitor resistance 💬
 [2] EGFR, ERBB2 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
10 EGFR tyrosine kinase inhibitor resistance 💬
 [2] EGFR, ERBB2 💬 Neratinib 💬 Neratinib [1] 34 💬
11 EGFR tyrosine kinase inhibitor resistance 💬
 [3] EGFR, ERBB2, KDR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
12 EGFR tyrosine kinase inhibitor resistance 💬
 [1] FGFR2 💬 Palifermin 💬 Palifermin [5] 13, 36, 38, 39, 65 💬
13 EGFR tyrosine kinase inhibitor resistance 💬
 [2] FGFR2, FGFR3 💬 Infigratinib 💬 Infigratinib [1] 276 💬
14 EGFR tyrosine kinase inhibitor resistance 💬
 [5] FGFR2, FGFR3, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
15 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IGF1R 💬 Linsitinib 💬 Linsitinib [1] 232 💬
16 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IGF1R 💬 Mecasermin 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
17 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IGF1R 💬 Teprotumumab 💬 Teprotumumab [1] 51 💬
18 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
19 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
20 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
21 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
22 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
23 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
24 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [3] 11, 13, 86 💬
25 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
26 EGFR tyrosine kinase inhibitor resistance 💬
 [1] JAK1 💬 Abrocitinib 💬 Abrocitinib [1] 84 💬
27 EGFR tyrosine kinase inhibitor resistance 💬
 [1] JAK1 💬 Filgotinib 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
28 EGFR tyrosine kinase inhibitor resistance 💬
 [1] JAK1 💬 Itacitinib 💬 Itacitinib [4] 46, 51, 97, 228 💬
29 EGFR tyrosine kinase inhibitor resistance 💬
 [1] JAK1 💬 Upadacitinib 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
30 EGFR tyrosine kinase inhibitor resistance 💬
 [2] JAK1, JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
31 EGFR tyrosine kinase inhibitor resistance 💬
 [2] JAK1, JAK2 💬 Peficitinib 💬 Peficitinib [1] 46 💬
32 EGFR tyrosine kinase inhibitor resistance 💬
 [2] JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬
33 EGFR tyrosine kinase inhibitor resistance 💬
 [2] JAK1, JAK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
34 EGFR tyrosine kinase inhibitor resistance 💬
 [1] KDR 💬 Axitinib 💬 Axitinib [1] 34 💬
35 EGFR tyrosine kinase inhibitor resistance 💬
 [1] KDR 💬 Cediranib 💬 Cediranib [1] 34 💬
36 EGFR tyrosine kinase inhibitor resistance 💬
 [3] KDR, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
37 EGFR tyrosine kinase inhibitor resistance 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
38 EGFR tyrosine kinase inhibitor resistance 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
39 EGFR tyrosine kinase inhibitor resistance 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
40 EGFR tyrosine kinase inhibitor resistance 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
41 EGFR tyrosine kinase inhibitor resistance 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
42 EGFR tyrosine kinase inhibitor resistance 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
43 EGFR tyrosine kinase inhibitor resistance 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
44 EGFR tyrosine kinase inhibitor resistance 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
45 EGFR tyrosine kinase inhibitor resistance 💬
 [1] PDGFRA 💬 Imatinib 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
46 EGFR tyrosine kinase inhibitor resistance 💬
 [2] PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
47 EGFR tyrosine kinase inhibitor resistance 💬
 [2] PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
48 EGFR tyrosine kinase inhibitor resistance 💬
 [2] PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
49 EGFR tyrosine kinase inhibitor resistance 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
50 EGFR tyrosine kinase inhibitor resistance 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
51 EGFR tyrosine kinase inhibitor resistance 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
52 EGFR tyrosine kinase inhibitor resistance 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
53 EGFR tyrosine kinase inhibitor resistance 💬
 [1] SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
54 EGFR tyrosine kinase inhibitor resistance 💬
 [1] SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
55 EGFR tyrosine kinase inhibitor resistance 💬
 [1] VEGFA 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
56 EGFR tyrosine kinase inhibitor resistance 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
57 EGFR tyrosine kinase inhibitor resistance 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬