Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

PPAR signaling pathway 💬

[1] APOC3 💬

Volanesorsen 💬

[1] 265 💬

2

PPAR signaling pathway 💬

[4] CPT1A, CPT1B, CPT1C, CPT2 💬

Perhexiline 💬

[2] 58, 272 💬

3

PPAR signaling pathway 💬

[1] PPARA 💬

Bezafibrate 💬

[7] 20, 93, 94, 160, 296, 316, 324 💬

Disease ID	Name
20	Adrenoleukodystrophy;ALD;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
94	Primary sclerosing cholangitis;PSC;
160	Congenital ichthyosis;
296	Biliary atresia;
316	Carnitine cycle disorder;
324	Methylglutaconic aciduria;

4

PPAR signaling pathway 💬

[1] PPARA 💬

Elafibranor 💬

[2] 93, 94 💬

5

PPAR signaling pathway 💬

[1] PPARA 💬

Fenofibrate 💬

[6] 8 , 79, 93, 94, 97, 265 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
79	Homozygous familial hypercholesterolemia;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
94	Primary sclerosing cholangitis;PSC;
97	Ulcerative colitis;
265	Lipodystrophy;

6

PPAR signaling pathway 💬

[1] PPARA 💬

Pemafibrate 💬

[1] 93 💬

7

PPAR signaling pathway 💬

[1] PPARG 💬

Bocidelpar 💬

[1] 113 💬

8

PPAR signaling pathway 💬

[1] PPARG 💬

Leriglitazone 💬

[1] 20 💬

9

PPAR signaling pathway 💬

[1] PPARG 💬

Pioglitazone 💬

[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
20	Adrenoleukodystrophy;ALD;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
229	Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP;
265	Lipodystrophy;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

10

PPAR signaling pathway 💬

[1] PPARG 💬

Rosiglitazone 💬

[5] 46, 75, 97, 222, 265 💬

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