Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

cGMP-PKG signaling pathway 💬

[2] ADORA1, ADORA3 💬

[3] 13, 58, 65 💬

2

cGMP-PKG signaling pathway 💬

[2] ADORA1, ADORA3 💬

Adenosine phosphate 💬

Adenosine phosphate

[1] 46 💬

3

cGMP-PKG signaling pathway 💬

[4] ADORA1, PDE2A, PDE3A, PDE3B 💬

Aminophylline 💬

[1] 63 💬

4

cGMP-PKG signaling pathway 💬

[4] ADORA1, PDE2A, PDE3A, PDE3B 💬

Theophylline 💬

[2] 236, 299 💬

5

cGMP-PKG signaling pathway 💬

[4] ADORA1, PDE2A, PDE3A, PDE3B 💬

Theophylline 💬

[2] 236, 299 💬

6

cGMP-PKG signaling pathway 💬

[5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

7

cGMP-PKG signaling pathway 💬

[5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬

Caffeine hydrate 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

8

cGMP-PKG signaling pathway 💬

[1] ADORA3 💬

Piclidenoson 💬

[1] 46 💬

9

cGMP-PKG signaling pathway 💬

[1] ADRA1A 💬

[1] 13 💬

10

cGMP-PKG signaling pathway 💬

[1] ADRA1A 💬

[2] 6 , 13 💬

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